The purpose of this study was a comparative assessment of pathological changes in the morpho-functional condition of the heart in groups of patients with arterial hypertension, divided by salt sensitivity.

Material and methods. 93 patients with arterial hypertension (AH) and concomitant coronary heart disease were included in the study. All patients were subjected to a salt load, after which all patients were divided into groups of salt-sensitive (SS) and nonsalt-sensitive (NSS) patients. Along with this, the patient was replicated with an echocardiographic examination of the heart to determine the functional state of the heart muscle. Patients in the SS and NSS groups were compared by heart echocardiography results.

Results. Left ventricular hypertrophy was found to be more prevalent in the group of SS patients compared to the NSS group (82.6% vs. 17.0%) and the differences between the groups were statistically significant (p<0.001). In many cases, some echocardiographic parameters, such as left ventricular posterior wall thickness and intra-ventricular thickness, were higher in patients with SS, which indicated significant early remodeling of the heart in these patients.

Conclusions. The obtained data allow us to judge about the more pronounced and early occurrence of myocardial hypertrophy in SS patients.

To date, there is a sufficient amount of data on the nature of diseases associated with the risk of sudden death. It is shown that many of them are genetically determined, and this is particularly dangerous, since not only the patient who has been diagnosed with the disease, but also his children and close relatives are at risk. Such diseases are rarely detected in normal clinical practice, and patients die, as a rule, not in specialized hospitals, but at home or on the street, and the doctor of the polyclinic or the ambulance crew remains to state the death. Cardiologists often pay attention only to the first symptoms of the disease, primarily syncope and palpitations, but also often the first and last manifestation of the disease is sudden death. Modern clinical medicine identifies a number of diseases and syndromes that are closely associated with a high risk of sudden death at a young age. These include one of the most «mysterious» diseases — Brugada syndrome (SB).

Among the large number of benign tumors of the heart myxoma most frequently diagnosed neoplasm intracavitary (occurs in 50%). The clinical picture of a myxoma is extremely various. Often it is diagnosed as a casual find. Usually the diagnosis is established according to an echocardiography. Magnetic resonance imaging is used for inspection of patients with suspicion on myxoma in cases when information of echocardiography is not enough and before surgical treatment. We present clinical follow-up 58 years old patients with left atrial myxoma, which before surgical treatment has executed a heart MRI.

Purpose. To describe a clinical case of coronary burden without stenosing lesions of the main branches of the coronary arteries in a patient with microvascular angina with subsequent development of myocardial infarction with the formation of ischemic hypokinesis of the anterior-apical region of the left ventricle in the absence of elevated levels of serum markers of myocardial necrosis.

Materials and methods. The study is based on a single clinical case. The object of the study is the patient in whom there were complaints of pressing pain localized behind the sternum and radiating to the left arm, accompanied by a mixed shortness of breath that occurred at rest, poorly stoped short-range nitrates and narcotic analgesics, sharp General weakness. Under primary inspection state of ailing average extent of gravity, consciousness clear, position active, skin integuments and visible mucous of clean, conventional painting. The patient was evaluated laboratory parameters, ECG, echo-cardiography (ECHO-kg), chest x-ray (OGK), coronary angiography (CAG), followed by transfer to the emergency Department of cardiology.

Results. The conducted clinical and laboratory study revealed the presence of leukocytosis in the patient with the clinic of acute coronary syndrome, without increasing cardiospecific enzymes (CFC, CFC-MB, troponin test), as well as high activity of coagulogram indicators (fibrinogen, ACTV, rfmc). When conducting radiography of OGK in direct projection-congestive lungs, a picture of chronic bronchitis in combination with left ventricular myocardial hypertrophy.

Conclusion. In the presented clinical case was described an example of development of microvascular lesions in coronary arteries in a patient with manifestation of acute coronary syndrome with severe prolonged chest pain and repolarization changes on ECG and without elevated levels of serum markers of myocardial necrosis, which probably leads to the definition of this state as fragile (or sharp) microvascular dysfunction with myocardial infarction.