SYSTEMIC DISORDERS IN PATIENTS WITH CARDIOMYOPATHY: BIOCHEMICAL PROFILE DEPENDING ON THE CLINICAL FORM OF THE DISEASE

Abstract

Actuality. Condition of hepatopathy being quite common in patients with dilated cardiomyopathy has a special, pathognomonic value at right ventricular cardiomyopathy, as hepatic congestion develops already in the early stages of the disease. Its development was greatly exacerbates the underlying disease, increases symptoms and worsens the general state of patients. The aim. Explore the features of deviations in the biochemical analysis, and the relationship between impaired liver function and the type of damage to the heart in various forms of cardiomyopathy Materials and methods. The study included 52 patients with CHF II-IV of NYHA classes, due to idiopathic dilated ( DCM ) and right ventricular (RV DCM ) dilated cardiomyopathies. All patients were assessed a clinical status, transthoracic echocardiography and blood biochemical investigation. Results. It has been shown that RVDCM in 2 times more common in women, is characterized by more frequent occurrence of signs of hepatopathy (81,8 % vs. 43,3 %), in the form of increased levels of bilirubin (mainly due to indirect fractions 14,82 ± 16,21mkmol / l vs. 6,76 ± 3,51 mkmol / l), transaminases ( 36,3 % and 30 %) and the relative hypoalbumin (2,9 ± 0,6 g / dl vs. 3,16 ± 0,48 g / dl ), hypocholesterolemia in this group of patients.