No 3 (2016)
SHORT MESSAGES
ORIGINAL PAPERS
6-12 313
Abstract
Purpose: to evaluate the parameters of the central aortic pressure and arterial stiffness during the day in patients with arterial hypertension (AH) with metabolic syndrome (MS) Material and methods: The study included 48 subjects divided into 2 groups: 23 (47,9%) subjects with AH, 25 (52,1%) subjects with AH with MS (AH+MS). Control group (CG) were 22 practically healthy subjects. All the subjects underwent examination ABPM with oscillometric sensor (BPLabVasotens, Russia) with assessment CAP (systolic blood pressure, SBPao; diastolic blood pressure DBPao; pulse pressure,PPao; Augmentation index, Alxao; amplification of pulse pressure, PPA) and arterial stiffness (pulse wave velocity, PWVao; Reflected Wave Transit Time, RWTT; Arterial Stiffness Index, ASI; Augmentation index, AIx). Results: Analysis of CAP demonstrated significant differences between the day / night SBP ao, DBP ao., mean BP ao in AH and AH + MS groups compared to the CG. No significant differences in the parameters of pulse pressure (PP) during the day in these groups are not mentioned, but PP is higher in AH + MS group. Augmentation Index for 24 hours significantly higher, amplification of pulse pressure was significantly lower in the AH + MS compared to CG and AH group. Evaluation of daily arterial stiffness parameters revealed significantly higher rates in PWVao in AH + MS group comparison with the CG and AH group. RWTT statisticaly significant lower in AH + MS and AH groups compared to CG. Conclusion: 24-hour monitoring of CAP and AS revealed a deterioration of the elastic properties of central arteries in hypertensive subjects with metabolic syndrome. Thus, the results of our study confirm the importance of the study of arterial stiffness and the CAP and in the long term could be considered as markers in hypertensive patients, especially in the presence of comorbid pathology.
14-21 4165
Abstract
Aim. Compare the effectiveness of nebivolol and sotalol in patients with hypertensive disease (HD) and ventricular arrhythmias (VA) taking into account its effect on regulatory adaptive status (RAS). Materials and methods. 49 patients with HD of stages II-III and VA of grade I-IV based on the В.Lown grading system, II-III groups based on J.Bigger grading system took part in the research, they were randomized into two groups for treatment with nebivolol (6,9±1,8 mg/day) or sotalol (159,1±47,4 mg/day). As part of combination therapy, patients were administered lisinopril (13,9±3,7 mg/day and 13,7±4,5 mg/day), acetylsalicylic acid when required (90,0±14,6 and 95,0±16,2 mg/day), atorvastatin (18,7±4,1 mg/day and 15,6±4,9 mg/day), respectively. Initially and 6 months after therapy, the following was done: quantitative assessment of RAS (by cardio-respiratory synchronism test), echocardiography, triplex scanning of common carotid arteries, treadmill test, six-minute walk test, all-day monitoring of blood pressure and electrocardiogram, subjective assessment of quality of life. Results. Both drug regimens comparably improved structural and functional condition of the heart, increased controlled arterial hypertension, effectively suppressed ventricular arrhythmia, improved the quality of life. Nebivolol positively affected the RAS and increased exercise tolerance more. Conclusion. In patients with HD of stages II-III and VA as part of combination therapy the use of nebivolol may be preferable to sotalol due to its positive impact on the RAS.
REVIEW
V. I. Stelmashok,
O. L. Polonetsky,
N. P. Strygo,
A. O. Zatsepin,
E. V. Belsky,
A. N. Zakharevich,
A. G. Mrochek
22-29 423
Abstract
In article it was resumed modern concepts of interventional chronic total occlusion retrograde recanalization. It was introduced advantages and disadvantages of particular approaches. It was described created by authors new way of retrograde CTO recanalization (CART-M method) and clinical presentation of this method was shown. It was announced potential advantages of CART-M method comparing with other methods of CTO recanalization.
30-40 429
Abstract
Key points of using non-invasive methods for evaluating myocardial ischemia (exercise electrocardiogram, stress echocardiography, single photon emission computed tomography and myocardial perfusion imaging with stress-test) in clinical practice to determine the functional significance of intermediate coronary artery stenoses (50-70% of the vascular lumen) are discussed in the review.
BOOK OF ABSTRACTS
46 204
Abstract
One of the most important medical and social problems are acute cerebrovascular disorders, among which the most part is ischemic stroke. Known that in the development of stroke leading role belongs to endothelial dysfunction (ED), the main manifestation of which is the metabolic changes of the vascular wall, the release of a significant amount endothelin-1 (EDN1) and the development of vasoconstriction. Therefore, one of the candidate genes, polymorphisms that can be associated with a predisposition to the development of ED and consequently contribute to stroke, is EDN1 gene. In order to improve the prevention of stroke, we decided carry out a study among healthy persons and identify possible susceptibility. The aim of our study was to analyze the association Lys198Asn polymorphism of EDN1 gene with ischemic atherothrombotic stroke (IAS) risk factors in the Ukrainian population.
48 245
Ю. Персидских,
А. Мрочек,
Т. Ильина,
Д. Гончарик,
А. Часнойть,
В. Барсукевич,
Л. Плащинская,
Е. Ковш,
А. Савченко
56-57 210
67 213
79 183
Д. Гончарик,
А. Мрочек,
Л. Плащинская,
А. Савченко,
В. Барсукевич,
А. Часнойть,
О. Коваленко,
Д. Севрукевич,
Ю. Персидских
112-113 220
А. Полупанов,
А. Концевая,
Ж. Мамасаидов,
А. Халматов,
Т. Романова,
Н. Ческидова,
А. Алтымышева,
А. Джумагулова
149-150 200
174 258
193-194 161
Abstract
To study specific features of the development and progressing of the acute coronary syndrome and acute myocardial infarction in men in different age groups in one of the districts of Tashkent.
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INSTRUCTIONS TO AUTHORS
ISSN 2225-1685 (Print)
ISSN 2305-0748 (Online)
ISSN 2305-0748 (Online)
