This research was aimed to study the possibilities of multislice computed (MSCT) tomography to diagnose status of coronary arteries at the patients with ischemic heart diseases. Material and methods. The research includes the results of complex study of 70 patients, which were send to the cardiology department for the verification of ischemic heart disease, as well as for examination and correction of provided therapy at this category. All patients had been provided traditional invasive coronary angiography and MSCT of coronary arteries. Results. At the 29 (76,3%) patients of 1 group stenosis of coronary arteries were not revealed, in 6 (15,8%) patients were revealed insignificant hemodynamic stenosis. In 3 (7,9%) patients revealed significant hemodynamic stenosis and in 1 (2,6%) critical stenosis (narrowing coronary artery lumen КА > 90 %). By data of MSCT and coronary angiography was revealed strong correlative relationship in diagnosis of stenosis. These factors argue about high comparability of both methods. The greatest correlation relationship was revealed for trunk of left coronary artery, right descending artery and circumflex artery and was 9,2; 0,84 and 0,81 accordingly. Analogical indexes were less for the right coronary artery and was 0,71. Though, large part of the patients in main group was not needed in intracoronary intervention and surgical revascularization. Conclusion. MSCT can use as noninvasive alternative method of coronary angiography in patients with high risk of ischemic heart disease. Comparative analysis of MSCT of coronary arteries and invasive coronary angiography revealed that MSCT has sensitivity of 91%, specificity of 89%.

In the recent years there is a tendency for progressive increase in the number of patients with chronic kidney failure (CKF) in the world and, importantly, that this growth does not tend to slow down in the future. Numerous studies have proven a clear relationship between the degree and duration of arterial hypertension (AH) and incidence of CKF. in this view during AH glomerular filtration rate (GFR) reflects early, intermediate and also late stages of kidney damage and in this case changes of GFR have diverse character. so, an increase of absolute values of GFR is typical for early stages of AH and a decrease of GFR is typical for the late stages of AH. in the same time during AH GFR can be presented as a predicting risk factor for other target organ damage and cardiovascular morbidity and mortality development as well. Thus the evaluation of GFR should be more widely introduced in the clinical practice with the purpose of revelation of other cardiovascular risk factors and associated pathological conditions, continuous monitoring and prevention of target organ damage.

The article presents a comparative analysis of the results obtained by the invasive treatment in patients with post-infarction angina. In own clinical material authors demonstrate high efficacy of endovascular and surgical treatment carried out in persons with urgent indications Q-myocardial infarction and unstable post-infarction angina. Furthermore, analysis of the frequency and nature of the main causes of complications in various kinds of surgery has been performed. The study found that the development of the final outcome is significantly affected not only by the initial severity of the patient's condition, but also by the selection of the most adequate method of myocardial revascularization. To increase the effectiveness of invasive treatment further improvement and implementation of new technologies of the restoration of coronary blood flow in patients with acute coronary syndrome is offered.

The aim. Studying of influence of the control glycaemia on development of diastolic dysfunction and remodelling of left ventricular in patients with type 2 diabetes mellitus (DM) with presence or absence of essential arterial hypertension was evaluated. Material and methods. In 133 patients with DM aged 26 to 66 years without ischemic heart disease the echocardiography with estimation of diastolic properties and diagnostics of remodeling of left ventricular has been investigated. Results. The diastolic dysfunction in 25.9% and remodeling of left ventricular in 35.4% patients with DM without essential arterial hypertension were observed. Poor compensation of DM (level of HbAlc >7,5 %), which was accompanied by more often development of demyelinating neuropathy, resulted in weighting of diastolic dysfunction and remodelling of left ventricular as with presence, and absence of the essential arterial hypertension in patients with diabetes. Conclusion. Absence of indemnification of exchange of the carbohydrates in patients with MD irrespective of presence of arterial hypertension associates with more expressed remodelling of the hearts.

Background. The study of genes polymorphism of angiotensinconverting enzyme (ACE) and their contribution to development and clinical course of dilated cardiomyopathy (DCM), and the possibility of early diagnostics and differentiated pharmacotherapy in early and advanced stages of the disease, is a promising new area of medical genetics and cardiology research. The aim. To study the genes polymorphism of angiotensinconverting enzyme (ACE) at DCM patients in the Uzbek population, to reveal the feature of heart remodeling depending on a genotype, and also an estimation of Lisinopril efficiency at these patients. Material and methods. It has been surveyed 102 DCM patients of the Uzbek nationality, with II-IV classes by NYHA. Besides an estimation of the clinical status (test of six-minute walking, clinical status estimation score (in Mareev modification) it has been spent 12-led ECG, EchoCG, Holter ECG, rentgenkardiometriya. These data were analyzed depending on the revealed genotype. Results. For the first time we have studied the genes polymorphism at Uzbek DCM patients. It has been showed feature of clinical and instrumental data depending on genotype, and also revealed unfavorable types of gene inheritance. It has been noted a high efficiency of Lisinopril application at DCM patients depending on the ACE- genes polymorphism.