Aim. The aim of this randomized clinic trial was to study 5-year follow up of morbidity and mortality in patients with acute coronary syndrome after conducted multivessel percutaneous transluminal coronary angioplasty (PTCA).

Material and methods. The trial was carried out in two groups with EF 35% for assessment of acute coronary syndrome impact to myocardial revascularization. 742 patients were included to the trial. All patients were undergone coronary angiography admitted during 6 hours after MI and followed through PTCA. 5 year follow-up of morbidity was investigated on these patients considering an initial EF.

Results. 129 patients had got EF indices lower than 35%. Only 122 patients (94%) among these ones completed the 5 year follow up. 613 patients had got EF with initial indices higher than 35%. Average age of patients with EF 35% - 55,8 year (SD 10-17). 110 patients (90,2%) with EF 35% were men. 12 (9,8%) women were in the group with EF35%. Only 577 (93,8%) of them completed the follow up. The estimation of morbidity and mortality were done in divided groups by EF for both sex. Also there were investigated and compared the causes of death in both groups.

Conclusion. EF was determined as an important factor influenced morbidity and mortality in patients after PTCA.

The application of the medical standard HL7 CDA for the tasks of creating clinical documents and digital signature means suitable for use in a single information space is described. A new specification (FHIR standard) is presented, based on the latest approaches in the field of e-health, but taking into account all the accumulated experience (real needs, successful solutions and typical difficulties). The structure of the electronic medical map (EMC), the conceptual, logical and physical model of the database for the needs of the cardiological service, which is the core of the unified information space of the RSSPMCC, is developed.

The aim of this study was to investigate the heart and common carotid arteries (CCA) morphological and functional condition and the lipid spectrum in patients with arterial hypertension (AH) and type 2 diabetes mellitus (DM-2).

Material and methods. The study included 144 patients with varying degrees of AH, 103 had AH without DM-2 (AH subgroup) and 41 patients with AH and DM-2 (AH+DM-2 subgroup). In all investigated patients the blood plasma lipid profile, echocardiographic examination of the heart and ultrasound Doppler examination of the CCA were carried out.

The results. Significant differences between the AH and AH+DM-2 subgroups were discovered, which confirmed the significant effect of DM-2 on various parameters of the cardiovascular system. The lipid profile in the above mentioned subgroups has not significant differences, but some separated indices (TG, VLDL) in the AH+DM-2 subgroup were comparatively higher and HDL level lower comparing to AH subgroup. Marked changes in echocardiographic parameters, such as lowering of left ventricle (LV) ejection fraction (EF), significant increase of interventricular septum and LV posterior wall thickness, high frequency of LV hypertrophy detection, diastolic dysfunction, diffuse hypokinesis and dilatation of the heart cavities in the AH+DM-2 subgroup were confirmed. A significant rise of CCA intima-media thickness also was found in the AH+DM-2 in comparison with AH subgroup, which proved the essential role of comorbidity of AH and DM-2 in the heart and vessels remodeling.

The conclusion. The results of the study confirm the role and significance of comorbidity of AH with DM-2 in the development of the cardiovascular system pathological changes.

<strong>The purpose</strong> of the study: to study the effectiveness of the use of the drug iloprost in patients with PH III - IV FC according to the register of the Voronezh region. The material was the base register data. The effectiveness of the drug «iloprost» evaluated in patients with PH III - IV FC according to the register. The safety of therapy «iloprost» shown on the basis of a complex of clinical and hemodynamic parameters.Glinical example presented.