Effect of endovascular closure of the patent foramen ovale on the severity of symptoms of migraine with aura: a clinical study
https://doi.org/10.38109/2225-1685-2024-4-74-81
Abstract
Aim. To study the effect of endovascular closure of patent foramen ovale (PFO) on the severity of symptoms of migraine attacks in patients with migraine with a history of aura.
Materials and Methods. We analyzed the data of 74 patients with migraine with a history of aura who underwent endovascular closure of the PFO for the period from 2018 to 2022 at the E.I. Chazov National Medical Research Center of Cardiology. All patients underwent examinations that complied with clinical recommendations. The presence of a history of migraine with aura was determined through a patient interview, previous hospital history, and was confirmed by a neurologist. The severity of migraine symptoms was assessed using the MIDAS (Migraine Disability Assessment) scale before occluder implantation and after 36,9 [22,7; 50,8] months the intervention as part of a telephone contact.
Results. 49 patients before the intervention had pain syndrome assessed on the MIDAS scale <11 points, in 25 patients the MIDAS score was ≥11 points. The technical success of the intervention was 100%. In the long–term period, the average MIDAS score in the group of patients with baseline MIDAS <11 was 0.00 [0.00; 5.00] points, and in the group with baseline MIDAS ≥11 was 15.00 [14.00; 15.00] points (p<0,0001). After 36,9 [22,7; 50,8] months occluder implantation, the average MIDAS score decreased by 75.0% in both groups (p<0,0001). The number of patients in the group with an initial MIDAS ≥11 points decreased by 80.0% compared to baseline values (p<0,0001).
Conclusion. Endovascular closure of the PFO in patients with migraine with a history of aura promotes significant regression of the pain syndrome.
About the Authors
A. S. Tereshchenko
E.I. Chazov National Medical Research Center of Cardiology
Russian Federation
Russian Federation
Andrey S. Tereshchenko, Cand. of Sc. (Med.), Senior Researcher, the Department of Endovascular Diagnostic and Treatment Methods
15a Akademika Chazovа st., Moscow 121552
E. V. Merkulov
E.I. Chazov National Medical Research Center of Cardiology
Russian Federation
Russian Federation
Evgeny V. Merkulov, Dr. of Sc. (Med.), Chief Researcher, the Department of Endovascular Diagnostic and Treatment Methods
15a Akademika Chazovа st., Moscow 121552
M. R. Azimova
E.I. Chazov National Medical Research Center of Cardiology
Russian Federation
Russian Federation
Makka R. Azimova, cardiologist of the 5th Cardiological Department
15a Akademika Chazovа st., Moscow 121552
O. A. Sivakova
E.I. Chazov National Medical Research Center of Cardiology
Russian Federation
Russian Federation
Olga A. Sivakova, Cand. of Sc. (Med.), Head of the 5th Cardiology Department
15a Akademika Chazovа st., Moscow 121552
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Review
For citations:
Tereshchenko A.S., Merkulov E.V., Azimova M.R., Sivakova O.A. Effect of endovascular closure of the patent foramen ovale on the severity of symptoms of migraine with aura: a clinical study. Eurasian heart journal. 2024;(4):74-81. (In Russ.) https://doi.org/10.38109/2225-1685-2024-4-74-81
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