THE ROLE OF N-TERMINAL PRO-C-TYPE NATRIURETIC PEPTIDE AS A DIAGNOSTIC BIOMARKER OF PULMONARY HYPERTENSION IN COPD PATIENTS
https://doi.org/10.38109/2225-1685-2015-4-26-31
Abstract
Objective. Available data on the diagnostic value of determination of the concentration N-terminal pro-C-type natriuretic peptide (Nt-proCNP) to predict pulmonary hypertension (PH) in patients with COPD are few. Aim. To determine the concentration of NT-proCNP in COPD patients and evaluate its diagnostic value for the prediction of PH in COPD. Methods. The study involved 47 patients with COPD (GOLD II-IV, age 59,49±0,63 years, disease duration 13,7±0,63 years, smoking history 23,09±0,93 packs/years). NT-proCNP concentration in serum was assessed by ELISA technique (test Biomedica Medizinprodukte GmbH & Co KG, Austria). The pulmonary artery systolic pressure (SPAP) was analyzed by using a color-Doppler technique. Results. Concentrations of NT-proCNP were significantly higher in COPD patients with PH (SPAP 40-55 mmHg, n=16) or severe PH (SPAP ≥55 mmHg, n=10) than in patients without PH (SPAP < 40 mmHg, n=21): 4.14±0.51 pg/ml, 5.26±0.21 pg/ml and 1.42±0.03 pg/ml (p<0.001), respectively. A significant correlation was found between the concentration of NT-proCNP and SPAP (r=0.53; p<0.05). The AUC for Nt-proCNP levels to predict PH and severe PH in COPD were 0.928 and 0.932, respectively. Conclusion. The present study shows that the serum levels of NT-proCNP are significantly elevated in COPD patients with PH and can be used as a non-invasive specific biomarker for predicting PH in COPD.
About the Authors
V. V. Gaynitdinova
Bashkir State Medical University
Russian Federation
Russian Federation
L. A. Sharafutdunova
Bashkir State University
Russian Federation
Russian Federation
S. N. Avdeev
Pulmonology Research Institute
Russian Federation
Russian Federation
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For citations:
Gaynitdinova V.V., Sharafutdunova L.A., Avdeev S.N. THE ROLE OF N-TERMINAL PRO-C-TYPE NATRIURETIC PEPTIDE AS A DIAGNOSTIC BIOMARKER OF PULMONARY HYPERTENSION IN COPD PATIENTS. Eurasian heart journal. 2015;(4):26-31. (In Russ.) https://doi.org/10.38109/2225-1685-2015-4-26-31
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