PROGNOSTIC SIGNIFICANCE OF TISSUE DOPPLER IMAGING IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY

Abstract

Objective: to assess the value of tissue Doppler (TD) imaging in predicting the clinical course of patients with hypertrophic cardiomyopathy (HCM). Materials and Methods: clinical and demographic data were analyzed in 212 subjects with HCM (141 males and 107 females, mean-age 45 yo). Median follow-up was 3,2 years (0,7-12,5 years). Patients were stratified into two groups: with present or absent adverse outcomes. Results: over the follow-up period, 7 fatal cases were registered due to SCD, and 4 successfully resuscitated subjects who experienced SCD received implantable pacemaker, 6 patients developed a stroke, cardiovascular death (1 patient) or hospitalization due to worsening of heart failure symptoms developed 7 patients. A statistically significant factor associated with adverse outcomes in cohort examined was возраст (OR 0,94; 95% CI 0,90 -0,98; p<0,001); LV outflow tract gradient (OR 1,04; 95% CI 1,01 -1,04; p<0,001); LAV/BSA (ОР 1,06; 95% CI 1,02 - 1,10; p<0,004) и E/Em lat (OR 1,37; 95% CI 1,12-1,67; p<0,002. Conclusions: there has been shown in our study that ratio E/ Em lat was the most significant prognosis factor: increasing of E/ Em by 1 CU followed by 37% increasing of relative risk of adverse effect appearance.