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FEATURES OF CORONARY ARTERIES LESION AT UNSTABLE ANGINA PATIENTS DEPENDING ON DISTRIBUTION OF APO С-III GENE POLYMORPHISM AND TYPE OF DISLIPIDEMIA

https://doi.org/10.38109/2225-1685-2014-3-30-36

Abstract

Aim. To study features of coronary arteries atherosclerotic lesions in unstable angina (UA) patients depending on distribution of APO С-III gene polymorphism and type of dislipidemia. Material and methods. There were examined 141 patients of Uzbek nationality with UA class IIB (Braunwald E. et al., 1989). The control group consisted of 50 healthy persons. DNA allocation made from blood by means of a set «Diatom™ DNA Prep 200» under the standard report of firm of the manufacturer (laboratory Isogene Russia). For carrying out PCR of amplification used a set (laboratory SibEnzyme, Russia). The sequence primers was used, according to recommendations Ahmad Reza Bandegi et al, 2011. Results. At the comparative analysis the distribution of S2 alleles SstI polymorphism of gene АРО C-III among the patients with UA in comparison with healthy persons, has been found a more prevalence of S2allelecarriers (HR 2,58, 95% CI 1,2-5,7, Р<0,05). In patients with carriage of S2 alleles it was observed raised triglycerides level (P <0,05) and high frequency of three-vessel coronary arteries lesion (HR 2,17, 95% CI 1,1-4,4, Р<0,05). At the comparative analysis in a subgroup of patients with triglycerides above a distribution median (>230 mg/dl) also prevailed S2 alleles carriers (HR 2,31, 95% CI 1,1-4,7, p <0,05) and occurrence of three-vessel coronary arteries lesion (HR 2,51, 95% CI 1,2-5,1, Р=0,003), whereas in a subgroup with triglycerides level <230 mg/dl have appeared more patients with one-vessellesion (HR 2,52, 95% CI 1,1-5,9, Р<0,05). Conclusion. Presence of three-vessel coronary arteries lesion among unstable angina patientsassociated with S2 alleles SstI polymorphism of gene АРО C-III carriage and hypertriglyceridemia.

About the Authors

A. S. Eshpulatov
Republican Specialized Center of Cardiology Ministry of Health of Uzbekistan
Russian Federation


S. U. Hoshimov
Republican Specialized Center of Cardiology Ministry of Health of Uzbekistan
Russian Federation


L. E. Kan
Republican Specialized Center of Cardiology Ministry of Health of Uzbekistan
Russian Federation


S. S. Ahmedova
Republican Specialized Center of Cardiology Ministry of Health of Uzbekistan
Russian Federation


S. A. Aminov
Republican Specialized Center of Cardiology Ministry of Health of Uzbekistan
Russian Federation


R. H. Trigulova
Republican Specialized Center of Cardiology Ministry of Health of Uzbekistan
Russian Federation


A. B. Shek
Republican Specialized Center of Cardiology Ministry of Health of Uzbekistan
Russian Federation


R. D. Kurbanov
Republican Specialized Center of Cardiology Ministry of Health of Uzbekistan
Russian Federation


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Review

For citations:


Eshpulatov A.S., Hoshimov S.U., Kan L.E., Ahmedova S.S., Aminov S.A., Trigulova R.H., Shek A.B., Kurbanov R.D. FEATURES OF CORONARY ARTERIES LESION AT UNSTABLE ANGINA PATIENTS DEPENDING ON DISTRIBUTION OF APO С-III GENE POLYMORPHISM AND TYPE OF DISLIPIDEMIA. Eurasian heart journal. 2014;(3):30-36. (In Russ.) https://doi.org/10.38109/2225-1685-2014-3-30-36

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ISSN 2225-1685 (Print)
ISSN 2305-0748 (Online)