VALUE OF VOLUME FRACTION OF COLLAGEN IN DEVELOPMENT OF MYOCARDIUM REMODELING ATTHE PATIENTS WITH INFLAMMATORY CARDIOMYOPATHY

Abstract

Objective. Studying of a possible role of interstitial fibrosis in remodeling of myocardium. Material and methods. For the purpose of estimation of fibrosis, depending on degree of dilatation of the left ventricle there has been carried out examination of 42 patients with inflammatory cardiomyopathy, (middle age 35,01±1,0). Patients have been divided into 2 groups. The first group was made of 23 patients with EDS <5,8 cm, and the second - 19 patients with EDS >5,8 cm. To all patients has been carried out ECG and EchoCG research. Results. At the patients of the 1st group CFV has made -9,1±2,2%, while in the 2nd group - 13,3±2,4%. By comparison of two groups of the patients substantial growth of collagen fraction volume at the patients with expressed dilatation of cavities of the left ventricles and its prevalence at the patients with heavy С is revealed more. At the patients with inflammatory cardiomyopathy thus the average index of distribution of collagen faction volume has made 11,1±3,1 % with fluctuations from 6 to 16 %. It is necessary to notice that in process of increase of signs of cardiac insufficiency CFV increases. So, at the patients with I-II CI FC CFV has made 9,8±3,0 % (CI 7,9-11,6), and at III - IV CI FC this indicator has increased already to 12,7±2,5 % (CI 11,0-14,4). The data obtained by us testifies that myocardium fibrosis at the patients with expressed cardiac insufficiency with dilatation of LV cavities much more, than at the patients with moderated СН. Conclusion. Thus, correlation between IMMLV and LVBW, which specifies dependence of structural changes on degree of fibrosis, and also the factors, promoting development of fibrosis at the patients with inflammatory cardiomyopathy is revealed.