The effect of correction of HF therapy based on indicators of multisensory ICD sensors on the clinical course of the disease and the frequency of shocks

Objective: to evaluate the effect of correction of HF therapy based on indicators of multisensory ICD sensors on the clinical course of the disease and the frequency of shocks.

Materials and methods. 111 patients with HF and indications for ICD implantation for the primary prevention of sudden cardiac death were included in the prospective study, then they were divided into two groups: in the studied (n=56) ICD with a multisensory set of sensors; in the comparison group (n=55), standard ICD without sensors. The patients were monitored for 12 months, and the dynamics of quality of life, clinical and laboratory parameters, device monitoring data, discharge episodes, and the number of hospitalizations due to HF decompensation were analyzed.

Results. The patient groups were initially comparable in terms of gender, age, etiology of the disease and severity of the condition. All patients were on optimal medication therapy for HF for more than 3 months. Initially, there were no significant differences in the level of NTpro-BNP and the six-minute walking test distance, and there were no еchocardiography indices in both groups. After 6 months, during device interrogation, diuretic therapy was changed in the study group, taking into account the indicators of multisensory sensors, in the comparison group only based on clinical data. After 12 months, both groups showed positive dynamics in the quality of life index; a significant increase in ejection fraction and NT-proBNP levels in the study group, a significant decrease in the six-minute walking test distance in the comparison group, a comparable number of both adequate and inadequate ICD discharges, and a significantly lower number of hospitalizations for decompensation in the study group.

Conclusion. The use of ICD multisensory monitoring was associated with a statistically significant improvement in the clinical course of HF and the frequency of shocks in patients compared with standard ICD.

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