Global longitudinal strain of the left ventricle of the heart in patients with both hypertrophic cardiomyopathy and stenotic lesion of the coronary arteries.
https://doi.org/10.38109/2225-1685-2026-1-20-26
Abstract
Research objective: to evaluate global longitudinal strain of the left ventricle in patients with hypertrophic cardiomyopathy (HCM) with different locations of myocardial thickening, with and without concomitant stenotic lesion of the coronary arteries. Materials and methods. Clinical data, echocardiography with speckle tracking echnology, and coronary angiography data from 69 patients with HCM aged 27 to 91 years were analysed. The optimal quantitative threshold for global longitudinal strain was determined by ROC analysis. Results. Echocardiography revealed septal HCM in 26 (37.7%) patients; symmetrical HCM in 18 (26.1%); combined variant in 14 (20.3%); apical variant in 9 (13%); and mid-ventricular variant in 2 (2.9%). Coronary angiography revealed stenotic lesions of the coronary arteries in 32 (46.4%) individuals with HCM. Global longitudinal strain in patients with HCM and concomitant stenotic lesion of the coronary arteries was > −11.2% (AUC 0.839). The degree of reduction in the indicator depended on the location of left ventricular thickening (AUC 0.867÷1). Obesity and reduced left ventricular ejection fraction in HCM reduced global longitudinal strain to > −8.5% (AUC 0.789) and > −7.4% (AUC 0.983), respectively. Conclusion. A decrease in global longitudinal strain of the left ventricle in patients with HCM suggests concomitant stenotic lesion of the coronary arteries: in the septal variant > −12.9%; symmetrical > −11.1%; apical > −10.2%. However, in each individual case, factors affecting global longitudinal strain of the left ventricle regardless of stenotic lesion of the coronary arteries should be taken into account: obesity and decreased left ventricular ejection fraction.
About the Authors
E. G. Akramova
Kazan (Volga region) Federal University
Russian Federation
Russian Federation
Endzhe G. Akramova, Dr. of Scien. (Med.), Associate Professor, Physician of the Ultrasound and Functional Diagnostics Departments, Medical and Sanitary Unit
Z. N. Akramova
Kazan State Medical University
Russian Federation
Russian Federation
Zilya N. Akramova, 6th-year student, Faculty of General Medicine
References
1. Деев И.А., Кобякова О.С., Стародубов В.И. и соавт. Заболеваемость всего населения России в 2023 году: статистические материалы. М.: ФГБУ «ЦНИИОИЗ» Минздрава России, 2024. с. 154. [Deev I.A., Kobyakova O.S., Starodubov V.I. et al. Morbidity of the entire population of Russia in 2023: statistical materials. Moscow: Federal State Budgetary Institution «TsNIIOIZ» of the Ministry of Health of the Russian Federation, 2024. p. 154. (in Russ.)]
2. Al Samarraie A., Petzl A., Cadrin-Tourigny J., Tadros R. Sudden Death Risk Assessment in Hypertrophic Cardiomyopathy Across the Lifespan: Reconciling the American and European Approaches. Heart Fail Clin. 2025;21(4):599-610. https://doi.org/10.1016/j.hfc.2025.07.002
3. Ommen S.R., Ho C.Y., Asif I.M. et al. 2024 AHA/ACC/AMSSM/ HRS/PACES/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy: A Report of the American Heart Association/ American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation. 2024;149(23):e1239-e1311. https://doi.org/10.1161/CIR.0000000000001250
4. Карпов Ю.А., Барбараш О.Л., Бощенко А.А. и соавт. Евразийские клинические рекомендации по диагностике и лечению стабильной ишемической болезни сердца (2020-2021). Евразийский кардиологический журнал. 2021;(3):54-93 [Karpov Yu.A., Barbarash O.L., Boschenko A.A. et al. Eurasian Guidelines for the diagnostics and management of stable coronary artery disease (2020-2021). Eurasian heart journal. 2021;(3):54-93. (in Russ.) https://doi.org/10.38109/2225-1685-2021-3-54-93 ]
5. Rhee T.M., Kim H.K., Kim B.S. et al. Impact of coronary artery revascularization on long-term outcome in hypertrophic cardiomyopathy patients: a nationwide population-based cohort study. Sci Rep. 2023;13(1):6412. https://doi.org/10.1038/s41598-023-33344-3
6. Wu S., Yang L., Sun N. et al. Impact of coronary artery disease in patients with hypertrophic cardiomyopathy. Hellenic J Cardiol. 2024;77:27-35. https://doi.org/10.1016/j.hjc.2023.08.002
7. Coleman J.A., Ashkir Z., Raman B., Bueno-Orovio A. Mechanisms and prognostic impact of myocardial ischaemia in hypertrophic cardiomyopathy. Int J Cardiovasc Imaging. 2023;39(10):1979-96. https://doi.org/10.1007/s10554-023-02894-y
8. Бокерия Л.А., Шляхто Е.В., Габрусенко С.А. и др. Гипертрофи ческая кардиомиопатия. Клинические рекомендации 2025. Рос сийский кардиологический журнал. 2025;30(5):6387. https://doi.org/10.15829/1560-4071-2025-6387 [Bokeria L.A., Shlyakhto E.V., Gabrusenko S.A. et al. 2025 Clinical practice guidelines for Hypertrophic cardiomyopathy. Russ J of Cardiol. 2025;30(5):6387. (In Russ.) https://doi.org/10.15829/1560-4071-2025-6387 ]
9. Mihos C.G., Liu J.E., Anderson K.M. et al. Speckle-Tracking Strain Echocardiography for the Assessment of Left Ventricular Structure and Function: A Scientific Statement From the American Heart Association. Circulation. 2025;152(10):e96-e109. https://doi.org/10.1161/CIR.0000000000001354
10. Gjergjindreaj M., Escolar E., Papadopoulos K., Mihos C.G. Assessment of left ventricular global longitudinal strain in patients with hypertrophic cardiomyopathy and coronary artery disease. Int J Cardiovasc Imaging. 2024;40(2):361-72. https://doi.org/10.1007/s10554-023-02994-9
11. Габрусенко С.А., Гудкова А.Я., Козиолова Н.А. и соавт. Гипертрофическая кардиомиопатия. Клинические рекомендации 2020. Российский кардиологический журнал. 2021;26(5):4541. https://doi.org/10.15829/1560-4071-2021-4541 [Gabrusenko S.A., Gudkova A.Ya., Koziolova N.A. et al. 2020 Clinical practice guidelines for Hypertrophic cardiomyopathy. Russian Journal of Cardiology. 2021;26(5):4541. (In Russ.) https://doi.org/10.15829/1560-4071-2021-4541 ]
12. Мацкеплишвили С.Т., Саидова М.А., Мироненко М.Ю. и соавт. Выполнение стандартной трансторакальной эхокардиографии. Методические рекомендации 2024. Российский кардиологический журнал. 2025;30(2):6271. https://doi.org/10.15829/1560-4071-2025-6271 [Matskeplishvili S.T., Saidova M.A., Mironenko M.Yu. et al. Standard transthoracic echocardiography. Guidelines 2024. Russian Journal of Cardiology. 2025;30(2):6271. (In Russ.) https://doi.org/10.15829/1560-4071-2025-6271 ]
13. Дедов И.И., Мокрышева Н.Г., Мельниченко Г.А. и соавт. Клинические рекомендации «Ожирение» Минздрава России. Версия 2024 года. Вестник репродуктивного здоровья. 2025;4(2):14-30. https://doi.org/10.14341/brh12763 [Dedov I.I., Mokrysheva N.G., Melnichenko G.A. et al. Clinical Guidelines "Obesity" of the Russian Ministry of Health. 2024 Version. Bulletin of reproductive health. 2025;4(2):14-30. (In Russ.) https://doi.org/10.14341/brh12763 ]
14. Mehri M., Campbell K.S., Lee L.C., Wenk J.F. A multi-scale finite element method for investigating fiber remodeling in hypertrophic cardiomyopathy. Sci Rep. 2025;15(1):31961. https://doi.org/10.1038/s41598-025-17778-5
15. Afonso L., Kondur A., Simegn M. et al. Two-dimensional strain profiles in patients with physiological and pathological hypertrophy and preserved left ventricular systolic function: a comparative analyses. BMJ Open. 2012;2:e001390. https://doi.org/10.1136/bmjopen-2012-001390
16. Karaca Özer P., Ayduk Gövdeli E., Engin B. et al. Role of global longitudinal strain in discriminating variant forms of left ventricular hypertrophy and predicting mortality. Anatol J Cardiol. 2021;25(12):863-71. https://doi.org/10.5152/AnatolJCardiol.2021.21940
17. Alnaimat S., Mascara M., Pulipati Y. et al. Case Series of the «Blueberry-on-Top» Phenomenon: A Recently Recognized Strain Pattern in Patients With Apical Variant Hypertrophic Cardiomyopathy. Echocardiography. 2026;43(1):e70368. https://doi.org/10.1111/echo.70368
Review
For citations:
Akramova E.G., Akramova Z.N. Global longitudinal strain of the left ventricle of the heart in patients with both hypertrophic cardiomyopathy and stenotic lesion of the coronary arteries. Eurasian heart journal. 2026;(1):20-26. (In Russ.) https://doi.org/10.38109/2225-1685-2026-1-20-26
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