Some features of slow-flow coronary syndrome in patients with long-term inflammation
A. V. Voynov,
O G. Zverev,
S. M. Lazarev,
L. I. Archakova,
A. F. Bokov,
O. P. Sokolova,
M. A. Rogachevskaya https://doi.org/10.38109/2225-1685-2025-4-62-65
Abstract
Introduction. The pathogenesis of slow flow coronary syndrome and its reversibility are not fully understood, which makes it difficult to treat these patients. Recently, there has been increasing evidence that inflammation plays a significant role in the development of these syndromes. The aim of this study was to investigate the functional or fixed nature of slow coronary blood flow and the potential reversibility of these changes in a chronic inflammation model.
Material and methods. The study included 19 patients with pulmonary tuberculosis who had signs of slowdown in coronary blood flow according to coronary angiography. A modified TIMI scale was used to assess the rate of movement of the radiocontrast agent. To assess the reversibility and possible functional nature of the changes, all angiographic studies were performed before and after intracoronary administration of 100 μg of nitroglycerin. The effects of antituberculosis chemotherapy and surgical treatment were evaluated.
Conclusions. The syndrome of slow coronary flow in patients with long-term chronic inflammation is not functional in most cases, but rather fixed. Conservative or surgical treatment aimed at eliminating the source of the inflammatory response is not accompanied by normalization of coronary flow.
About the Authors
A. V. Voynov
Pavlov First Saint Petersburg State Medical University; Saint-Petersburg State Phthisiopulmonology Research Institute
Russian Federation
Russian Federation
Alexey V. Voynov, Assistant, Department of Hospital Surgery; doctor, Department of X-ray surgical methods of diagnosis and treatment
6-8 L’va Tolstogo str., Saint Petersburg 197022
2-4 Ligovsky pr., Saint Petersburg 191036
O G. Zverev
Pavlov First Saint Petersburg State Medical University; Saint-Petersburg State Phthisiopulmonology Research Institute
Russian Federation
Russian Federation
Oleg G. Zverev, Dr. of Sci. (Med.), Professor, Department of Hospital Surgery; Head of the Department of X-ray Surgical Methods of Diagnosis and Treatment
6-8 L’va Tolstogo str., Saint Petersburg 197022
2-4 Ligovsky pr., Saint Petersburg 191036
S. M. Lazarev
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Sergey M. Lazarev, Dr. of Sci. (Med.), Professor, Department of Hospital Surgery
6-8 L’va Tolstogo str., Saint Petersburg 197022
L. I. Archakova
Saint-Petersburg State Phthisiopulmonology Research Institute; Saint-Petersburg State University
Russian Federation
Russian Federation
Liudmila I. Archakova, Dr. of Sci. (Med.), Deputy Chief Medical Officer; Associate Professor, Department of Hospital Therapy
2-4 Ligovsky pr., Saint Petersburg 191036
7/9 Universitetskaya embankment, Saint Petersburg 199034
A. F. Bokov
Saint-Petersburg State Phthisiopulmonology Research Institute
Russian Federation
Russian Federation
Aleksey F. Bokov, intern researcher, Department of X-ray surgical methods of diagnosis and treatment
2-4 Ligovsky pr., Saint Petersburg 191036
O. P. Sokolova
Saint-Petersburg State Phthisiopulmonology Research Institute
Russian Federation
Russian Federation
Olga P. Sokolova, Cand. of Sci. (Med.), Doctor of Anesthesiology and Resuscitation, Chief Doctor
2-4 Ligovsky pr., Saint Petersburg 191036
M. A. Rogachevskaya
Saint-Petersburg State University
Russian Federation
Russian Federation
Maria A. Rogachevskaya, student of the 6th year of medical faculty
7/9 Universitetskaya embankment, Saint Petersburg 199034
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Review
For citations:
Voynov A.V., Zverev O.G., Lazarev S.M., Archakova L.I., Bokov A.F., Sokolova O.P., Rogachevskaya M.A. Some features of slow-flow coronary syndrome in patients with long-term inflammation. Eurasian heart journal. 2025;(4):62-65. (In Russ.) https://doi.org/10.38109/2225-1685-2025-4-62-65
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