Interleukin-1β gene rs1143634 polymorphism and cardiovascular complications in patients with coronary artery atherosclerosis
https://doi.org/10.38109/2225-1685-2023-4-64-68
Abstract
The course of heart failure, regardless of its etiology, is associated with local and systemic activation of inflammatory signaling cascades. Identification of the association of candidate cytokine genes with the risk of developing coronary heart disease and chronic heart failure remains a subject of interest for many researchers. The review presents an analysis of studies of the rs1143634 polymorphism of the IL-β gene in relation to the risk of atherosclerotic cardiovascular complications. The presence of the minor allele T is associated with an increase in the concentration of IL-1β in the blood serum. Data on the role of the rs1143634 polymorphism of the IL-β gene in atherosclerotic coronary heart disease, including in combination with chronic heart failure syndrome, are presented, taking into account ethnic characteristics and gender of patients. The carriage of the T allele was associated with the risk of developing atherosclerosis and myocardial infarction. At the same time, it is reported that the C allele and the CC genotype of the rs1143634 polymorphism of the IL-1β gene were a genetic risk factor for the development and progression of heart failure. In a number of studies and meta-analyses, the association of this polymorphism with diseases of the cardiovascular system was not confirmed, but certain trajectories of the risk of complications were identified due to differences in the rs1143634 polymorphism of the IL-β gene in heart failure.
About the Authors
E. V. Khazova
Kazan State Medical University
Russian Federation
Russian Federation
Elena V. Khazova, Cand. of Sci. (Med)., associate professor, the department of propaedeutics of internal diseases named after Professor SS. Zimnitsky
Butlerov str., 49, Kazan 420012
O. V. Bulashova
Kazan State Medical University
Russian Federation
Russian Federation
Olga V. Bulashova, Dr. of Sci. (Med.), Professor, the department of propaedeutics of internal diseases named after Professor SS. Zimnitsky
Butlerov str., 49, Kazan 420012
E. V. Valeeva
Kazan State Medical University
Russian Federation
Russian Federation
Elena V. Valeeva, Cand. of Sci. (Biol.), Senior Researcher, the Central Research Laboratory
Butlerov str., 49, Kazan 420012
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Review
For citations:
Khazova E.V., Bulashova O.V., Valeeva E.V. Interleukin-1β gene rs1143634 polymorphism and cardiovascular complications in patients with coronary artery atherosclerosis. Eurasian heart journal. 2023;(4):64-68. (In Russ.) https://doi.org/10.38109/2225-1685-2023-4-64-68
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