CHARACTERISTICS OF CORONARY ATHEROSCLEROSIS IN PATIENTS WITH RHEUMATOID ARTHRITIS
https://doi.org/10.38109/2225-1685-2015-2-33-35
Abstract
Purpose of this study was examination of the features of coronary vessels in patients with rheumatoid arthritis (RA) using CT angiography. Materials and Methods: results of CT angiographic studies of 60 patients with varying degrees of coronary vessels pathology were retrospectively analyzed. 27 of them had a history of RA. The control group included 33 patients who had no medical history and clinical symptoms of rheumatic disease. The degree of calcification of the coronary arteries was calculated according to the Agatston degree. Processing of the results was carried out on Excel and Statistica 6.0. Results: The study found that coronary calcification in the control group patients averaged 289, and in patients with RA 305 HU (p <0.05). In addition, the dependence of the Agatston degree, patient's age, smoking and diabetes history was revealed. Conclusions: comparing to the control group coronary calcification was higher in patients with rheumatoid arthritis. A direct correlation between the value of the calcification index and RA activity, as well as risk factors such as age, smoking, and diabetes was revealed.
About the Authors
V. A. Azizov
Azerbaijan Medical University
Russian Federation
Russian Federation
M. D. Soltanova
Azerbaijan Medical University
Russian Federation
Russian Federation
T. A. Sadiqova
Azerbaijan Medical University
Russian Federation
Russian Federation
References
1. Gabriel S.E. The Epidemiology of Rheumatoid Arthritis. Rheum Dis Clin North Am 2001; 27(2):269-281.
2. Pincus T., Callahan L.F., Sale W.G., Brooks A.L., Payne L.E., Vaughn W.K. Severe functional decline, work disability and increased mortality in seventy-five rheumatoid arthritis patients studied over nine years. Arthritis Rheum 1984; 27(8):864-872.
3. Solomon D.H., Karlson E.W., Rimm E.B., Cannuscio C.C., Mandl L.A., Manson J.E. et al. Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis. Circulation 2003; 107(9):1303-1307.
4. Kitas G.D., Erb N. Tackling ischaemic heart disease in rheumatoid arthritis. Rheumatology 2003;42:607-13.
5. Насонов Е.Л. Ревматоидный артрит - модель атеротромбоза. РМЖ 2005;13:509-12.
6. Насонов Е.Л. Проблема атеротромбоза в ревматологии. Вестн РАМН 2003;7:6-10.
7. Попкова Т.В., Новикова Д.С., Насонов Е.Л. Атеросклероз при ревматических заболеваниях. В кн.: Ревматология: клинические рекомендации. M.: ГЭОТАР-Медиа, 2010;678-702.
8. Goodson N. Coronary artery disease and rheumatoid arthritis. Curr Opin Rheum 2002;14:115-20.
9. Huber S.A., Sakkinen P., Conze D., Hardin N., Tracy R. Interleukin-6 exacerbates early atherosclerosis in mice. Arterioscler Thromb Vasc Biol 1999; 19(10):2364-2367. 18
10. der Thusen J.H., Kuiper J., van Berkel T.J., Biessen E.A. Interleukins in atherosclerosis: molecular pathways and therapeutic potential. Pharmacol Rev 2003; 55(1):133-166.
11. Naruko T., Ueda M., Haze K., van der Wal A.C., van der Loos C.M., Itoh A. et al. Neutrophil infiltration of culprit lesions in acute coronary syndromes. Circulation 2002; 106:2894- 2900.
12. Ridker P.M., Cushman M., Stampfer M.J., Tracy R.P., Hennekens C.H. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 1997; 336(14):973-979.
13. Ridker P.M., Rifai N., Stampfer M.J., Hennekens C.H. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 2000; 101(15):1767-1772.
14. Nagata-Sakurai M., Inaba M., Goto H., Kumeda Y., Furumitsu Y., Inui K. et al. Inflammation and bone resorption as independent factors of accelerated arterial wall thickening in patients with rheumatoid arthritis. Arthritis Rheum 2003; 48(11):3061-3067.
15. Aubry M.C., Maradit-Kremers H., Reunalda M.C. et al. Differences in atherosclerotic coronary heart disease between subjects with and without rheumatoid arthriti. J Rheum 2007;34(5):937-42. 15. Raza K., Banks M., Kitas
16. Asanuma Y., Oeser A., Shintani A.K., Turner E., Olsen N., Fazio S. et al. Premature coronaryartery atherosclerosis in systemic lupus erythematosus. N Eng J Med 2003; 349(25):2407- 2415.
17. Fuchs H.A., Kaye J.J., Callahan L.F., Nance E.P., Pincus T. Evidence of significant radiographic damage in rheumatoid arthritis within the first 2 years of disease. J Rheumatol 1989; 16(5):585-591.
18. Залесский В.Н. Электронно-лучевая компьютерная томография: современные аспекты визуализации коронарного стеноза и кальциноза // Укр. мед. Часопис. - 2006. - №1. - С. 58-64.
19. Митьковская Н.П. Современные возможности ранней диагностики коронарного атеросклероза при метаболическом синдроме / Н.П. Митьковская, Е.А. Григоренко, Л.Л. Авдей // Весці НАН Беларуа Сер. мед. навук. - 2007. - № 4. - С. 108-113.
20. Терновой С.К. Неинвазивная диагностика атеросклероза и кальциноза коронарных арте- рий // С.К. Терновой, В.Е. Синицын, Н.В. Гагарина / М.: Атмосфера, 2003. - 144 с.
21. Vong N.D. Coronary artery calcium evaluation by electron beam CT and its relation to new cardiovascular events // Am. J. of Cardiol. - 2000. - Vol. - 86. - P. 495-498.
Review
For citations:
Azizov V.A., Soltanova M.D., Sadiqova T.A. CHARACTERISTICS OF CORONARY ATHEROSCLEROSIS IN PATIENTS WITH RHEUMATOID ARTHRITIS. Eurasian heart journal. 2015;(2):33-35. (In Russ.) https://doi.org/10.38109/2225-1685-2015-2-33-35
Views:
342
Email this article 
