PREVALENCE AND STRUCTURE OF CEREBROVASCULAR COMPLICATIONS OF ARTERIAL HYPERTENSION IN UZBEK PATIENTS WITH VARIOUS ANGIOTENSIN-CONVERTING ENZYME AND APOLIPOPROTEINE E. GENE POLYMORPHISMS
https://doi.org/10.38109/2225-1685-2012-2-55-58
Abstract
The purpose of the given work was frequency and structure studing cerebrovaskular complications at sick suffering hypertensive illness and revailing of their interrelation with polymorphism of genes ACE and APOE. Patients of both sexes at the age of 25-75 years suffering arterial hypertension (AH) 1 and 3 stages are for this purpose surveyed. Clinic-neurologic, biochemical and molekular-genetic research for definition of polymorphisms of genes ACE and APOE is for this purpose conducted. Are revealed to associate some polymorphisms of the studied genes with the heaviest complications AH.
About the Authors
N. U. Makhkamova
Republic Specialized Centre of Cardiology
Russian Federation
Russian Federation
A. I. Khodjayev
Republic Specialized Centre of Cardiology
Russian Federation
Russian Federation
References
1. Бойцов С. А. Десять лет поиска генетической основы гипертонической болезни: трудности и перспективы. Артер. гипертензия. - 2002. - Т. 8. - № 5. - С. 4-9.
2. Багмет А. Д. І/D полиморфизм гена ангиотензинпревращающего фермента, морфофункциональное состояние сердца и суточный профиль артериального давления у молодых мужчин с артериальной гипертонией. Терапевтический архив. - 2006- № 9. - С. 5-12.
3. Оганов Р. Г., Масленникова Г. Я., Шальнова С. А., Деев А. Д. Значение сердечно-сосудистых и других неинфекционных заболеваний для здоровья населения России. Профилактика заболеваний и укрепление здоровья 2002; 2: 3-7.
4. Чазова И. Е. Инсульт. Лечение артериальной гипертонии как профилактика ишемического инсульта. Приложение к Журн. неврол. и психиатр. им. С. С.Корсакова. 2001; 3: 3-7.
5. Henskens L. H., Spiering W., Stoffers H. E. et al. Effects of ACE I/D and AT1R-A1166C polymorphisms on blood pressure in a healthy normotensive primary care population: first results of the Hippocates study. J. Hypertension. - 2003. - Vol. 21, № 1. - P. 81-86.
6. Sierra C., Coca A., Gymez-Angelats E. et al. Renin-Angiotensin System Genetic Polymorphisms and Cerebral White Matter Lesions in Essential Hypertension. Hypertension. 2002. Vol. 39. (2) S. P. 343-347.
7. Verdecchia P., Angeli F., Borgioni C. et. al. Changes in cardiovascular risk by reduction of left ventricular mass in hypertension: a meta-analysis. Am J. Hypertens. 2003. Vol. 16. № 11, P. 895-899.
Review
For citations:
Makhkamova N.U., Khodjayev A.I. PREVALENCE AND STRUCTURE OF CEREBROVASCULAR COMPLICATIONS OF ARTERIAL HYPERTENSION IN UZBEK PATIENTS WITH VARIOUS ANGIOTENSIN-CONVERTING ENZYME AND APOLIPOPROTEINE E. GENE POLYMORPHISMS. Eurasian heart journal. 2012;(2):55-58. (In Russ.) https://doi.org/10.38109/2225-1685-2012-2-55-58
Views:
362
Email this article 
