Comparison of different classification of metabolic syndrome in the Kyrgyz ethnic group

Goal: Comparison of different classification of metabolic syndrome (MS) in Kyrgyz ethnic group. Materials and methods: 183 women, 140 men of the ethnic Kyrgyz, mean age 52,5 ± 8,5 years, were included in the study. Clinical examination, blood pressure, anthropometric data (weight, height, waist circumference, hip circumference), measurament, the analiysis of fasting glucose, lipid profile, insulin were perfomed in all examined persons. Diagnosis of MS was made using the criteria of ATP III (2005), IDF for European and asian populations (2005), Russian criteria (2009) and criteria of MS IDF and AHA / NHLBI (2009). Results: The sensitivity of detection of insulin resistance (IR) was high enough and did not differ significantly between the diagnostic criteria. The highest specificity 0,77 (0,72-0,83) occurred when criteria ATP III was used. The difference of specificity was close to significant between criterias of ATP III and IDF criteria for Asian populations and criteria MS IDF and AHA / NHLBI (2009), and reached statistical significance between the parameters of the ATP III, and Russian criteria. Conclusion: Based on these data, in Kyrgyz ethnic group for diagnosis of MS is preferebale the use of ATP III criteria.

абдоминальное ожирение, окружность талии, дислипидемия, критерии метаболического синдрома, abdominal obesity, dyslipidemia, criteria of metabolic syndrome

1. Third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA. 2001; 285: 2486-97.

2. Grundy S.M., Cleeman J.I., Daniels S.R., Donato K.A. et al. American Heart Association; National Heart, Lung, and Blood Institute. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005; 112:2735-2752.

3. Alberti K.G., Zimmet P., Shaw J. IDF Epidemiology Task Force Consensus Group. The metabolic syndrome: a new worldwide definition. Lancet. 2005; 366: 1059-1062.

4. Alberti M.M., Eckel R.H., Grundy S.M., Zimmet P.Z. et al. Harmonizing the Metabolic Syndrome. Circulation. 2009; 120:1640-1645.

5. Рекомендации экспертов всероссийского научного общества кардиологов по диагностике и лечению метаболического синдрома (Второй пересмотр). Всероссийское научное общество кардиологов. Москва. 2009; 32 с.

6. Fridewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 1972; 18:499-502.

7. Ford E.S. Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S. Diabetes Care 2005; 28: 2745-2749.

8. Assmann G., Guerra R., Fox G., Cullen P. et al. Harmonizing the definition of the metabolic syndrome: comparison of the criteria of the Adult Treatment Panel III and the International Diabetes Federation in United States American and European populations. Am J Cardiol. 2007; 99: 541-548.

9. Athyros V.G., Ganotakis E.S., Elisaf M.S. et al. Comparison of four definitions of the metabolic syndrome in a Greek (Mediterranean) population. Curr Med Res Opin. 2010; 26(3): 713-9.

10. Li Y., Zhao D., Wang W. et al. A comparison of three diagnostic criterions for metabolic syndrome applied in a Chinese population aged 35-64 in 11 provinces. Zhonghua Liu Xing Bing Xue Za Zhi. 2007; 28(1): 83-7.

11. Choi K.M., Kim S.M., Kim Y.E. et al. Prevalence and cardiovascular disease risk of the metabolic syndrome using National Cholesterol Education Program and International Diabetes Federation definitions in the Korean population. Metabolism. 2007; 56(4): 552-8.

12. Шалхарова Ж.С. Эпидемиология и клинические аспекты метаболического синдрома в Южном Казахстане. Автореф. дис..д-ра мед. наук. Алматы. 2006; 28 с.

13. Snehalatha C., Viswanathan V., Ramachandran A. Cutoff Values for Normal Anthropometric Variables in Asian Indian Adults. Diabetes Care. 2003; 26(5): 1380-1384.