evrazkarЕвразийский Кардиологический ЖурналEurasian heart journal2225-16852305-0748Евразийская ассоциация кардиологов10.38109/2225-1685-2026-2-68-75evrazkar-6603Research ArticleОБЗОРREVIEWПрогнозирование сердечно-сосудистых осложнений при микроваскулярной стенокардии: патогенез, маркеры риска и стратификацияPrediction of cardiovascular complications in microvascular angina: pathogenesis, risk markers, and stratificationhttps://orcid.org/0000-0002-1250-8798ХидироваЛ. Д.KhidirovaLyudmila D.

Хидирова Людмила Даудовна, д.м.н., профессор кафедры фармакологии, клинической фармакологии и доказательной медицины; кардиолог,

Красный проспект, 52, г. Новосибирск, 630091;

ул. Залесского, д. 6, корп. 8, г. Новосибирск, 630047.

Lyudmila D. Khidirova, Dr. of Scien. (Med.), Professor, Department of Pharmacology, Clinical Pharmacology, and Evidence-Based Medicine; cardiologist,

52, Krasny Prospekt, Novosibirsk, 630091;

6, Zalesskogo St., Bldg. 8, Novosibirsk, 630047.

h_ludmila73@mail.ruСулаймановН.SulaimanovNurzhan

Сулайманов Нуржан, врач отделения рентгенхирургических методов диагностики и лечения ОРМДиЛ,

ул. Залесского, д. 6, корп. 8, г. Новосибирск, 630047.

Nurzhan Sulaimanov, Physician, Department of X-ray Surgical Diagnostic and Treatment Methods,

6, Zalesskogo St., Bldg. 8, Novosibirsk, 630047.

ЛыковаА. А.LykovaAlena A.

Лыкова Алёна Александровна, врач-кардиолог,

ул. Залесского, д. 6, корп. 8, г. Новосибирск, 630047.

Alena A. Lykova, Cardiologist,

6, Zalesskogo St., Bldg. 8, Novosibirsk, 630047.

alena1003alena@ya.ruФГБОУ ВО Новосибирский государственный медицинский университет Минздрава России; ГБУЗ Новосибирской области «Новосибирский областной клинический кардиологический диспансер»РоссияNovosibirsk State Medical University; Novosibirsk Clinical Cardiology DispensaryRussian FederationГБУЗ Новосибирской области «Новосибирский областной клинический кардиологический диспансер»РоссияNovosibirsk Clinical Cardiology DispensaryRussian Federation202628052026026875Copyright © Хидирова Л.Д., Сулайманов Н., Лыкова А.А., 20262026Хидирова Л.Д., Сулайманов Н., Лыкова А.А.Khidirova L.D., Sulaimanov N., Lykova A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.heartj.asia/jour/article/view/6603

Проведен обзор современной российской и зарубежной литературы, посвященной проблеме нарушенного коронарного резерва кровотока как проявление микрососудистой дисфункции. При поиске информации по этому вопросу использованы материалы следующих баз данных: РИНЦ, Best Evidence, Scopus, Elsevier, PubMed, Clinical Evidence, Cochrane Library. Микроваскулярная стенокардия (МВС) представляет собой клинически значимую форму ишемической болезни сердца, характеризующуюся ишемией миокарда при отсутствии обструктивного поражения эпикардиальных коронарных артерий. В статье рассматриваются ключевые патогенетические механизмы развития сердечно-сосудистых осложнений у пациентов с МВС, а также современные биомаркеры и методы инструментальной визуализации, позволяющие проводить стратификацию риска и прогнозировать неблагоприятные исходы. Обсуждаются подходы к индивидуализации терапии и перспективы клинического мониторинга таких пациентов.

A review of modern Russian and foreign literature on the problem of impaired coronary blood flow reserve as a manifestation of microvascular dysfunction has been conducted. When searching for information on this issue, materials from the following databases were used: RSCI, Best Evidence, Scopus, Elsevier, PubMed, Clinical Evidence, Cochrane Library. Microvascular angina (MVA) is a clinically significant form of ischemic heart disease characterized by myocardial ischemia in the absence of obstructive epicardial coronary artery lesions. This review summarizes key pathophysiological mechanisms contributing to cardiovascular complications in patients with MVA, highlights modern biomarkers and imaging methods used for risk stratification and prognosis, and discusses therapeutic individualization and future directions in clinical monitoring.

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The authors declare that there are no conflicts of interest present.