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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">evrazkar</journal-id><journal-title-group><journal-title xml:lang="ru">Евразийский Кардиологический Журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Eurasian heart journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2225-1685</issn><issn pub-type="epub">2305-0748</issn><publisher><publisher-name>Евразийская ассоциация кардиологов</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.38109/2225-1685-2024-4-98-103</article-id><article-id custom-type="elpub" pub-id-type="custom">evrazkar-6490</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЙ СЛУЧАЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASE</subject></subj-group></article-categories><title-group><article-title>Клинический случай желудочно-кишечного кровотечения на фоне приёма двойной антиагрегантной терапии у пациента с ишемической болезнью сердца</article-title><trans-title-group xml:lang="en"><trans-title>A case report of gastrointestinal bleeding during dual antiplatelet therapy in a patient with coronary heart disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6761-1744</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Деева</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Deeva</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Деева Екатерина Сергеевна, врач-кардиолог, аспирант кафедры факультетской терапии № 1</p><p>Ул. Большая Пироговская, д. 6, стр. 1, г. Москва 119435</p></bio><bio xml:lang="en"><p>Ekaterina S. Deeva, cardiologist, Chair of Faculty Therapy № 1</p><p>6/1 Bol. Pirogovskaya st., Moscow 119435</p></bio><email xlink:type="simple">katydeeva@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6440-8636</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Исайкина</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Isaikina</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Исайкина Мария Алексеевна, к.м.н., доцент кафедры факультетской терапии № 1</p><p>Ул. Большая Пироговская, д. 6, стр. 1, г. Москва 119435</p></bio><bio xml:lang="en"><p>Maria A. Isaikina, Cand. Of Sci. (Med.), assistant professor, the Department of Faculty Therapy № 1</p><p>6/1 Bol. Pirogovskaya st., Moscow 119435</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5820-1759</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трушина</surname><given-names>О. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Trushina</surname><given-names>O. Iu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Трушина Ольга Юрьевна, д.м.н., профессор кафедры факультетской терапии № 1</p><p>Ул. Большая Пироговская, д. 6, стр. 1, г. Москва 119435</p></bio><bio xml:lang="en"><p>Olga Iu. Trushina, Dr. Of Sci. (Med.), Prof., Chair of Faculty Therapy № 1</p><p>6/1 Bol. Pirogovskaya st., Moscow 119435</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2682-4417</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фомин</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Fomin</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Фомин Виктор Викторович, чл.-корр. РАН, д.м.н., проф., проректор по инновационной и клинической деятельности, заведующий кафедрой факультетскойтерапии № 1</p><p>Ул. Большая Пироговская, д. 6, стр. 1, г. Москва 119435</p></bio><bio xml:lang="en"><p>Viсtor V. Fomin, Corresponding Member of the Russian Academy of Sciences, Dr. of Sci. (Med.), Prof., Pro-Rector for Innovation and Clinical Activity, Head of the Department of Faculty Therapy № 1</p><p>6/1 Bol. Pirogovskaya st., Moscow 119435</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-3344-8725</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Погонин</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pogonin</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Погонин Алексей Владимирович, к.м.н., главный врач</p><p>Каштановая аллея, д. 2, стр. 1, г. Москва, Зеленоград 124489</p></bio><bio xml:lang="en"><p>Alexey V. Pogonin, Cand. Of Sci. (Med.), chief physician</p><p>2/1 Kashtanovaya alleya, Moscow, Zelenograd 124489</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-8333-5854</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тамкаева</surname><given-names>М. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Tamkaeva</surname><given-names>M. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тамкаева Макка Казбековна, к.м.н., заместитель главного врача по медицинской части</p><p>Каштановая аллея, д. 2, стр. 1, г. Москва, Зеленоград 124489</p></bio><bio xml:lang="en"><p>Makka K. Tamkaeva, Cand. Of Sci. (Med.), deputy chief physician for medicine</p><p>2/1 Kashtanovaya alleya, Moscow, Zelenograd 124489</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет); Институт клинической медицины им. Н.В. Склифосовского</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University (Sechenov University); N.V. Sklifosovsky Institute of Clinical Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ  «Городская клиническая больница им. М.П. Кончаловского ДЗ  г. Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Budgetary Institution Konchalovsky City Clinical Hospital of Moscow City Health Department (Konchalovsky Clinic)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГБУЗ  «Городская клиническая больница им. М.П. Кончаловского ДЗ  г. Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Budgetary Institution Konchalovsky City Clinical Hospital of Moscow City Health Department&#13;
(Konchalovsky Clinic)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>23</day><month>11</month><year>2024</year></pub-date><volume>0</volume><issue>4</issue><fpage>98</fpage><lpage>103</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Деева Е.С., Исайкина М.А., Трушина О.Ю., Фомин В.В., Погонин А.В., Тамкаева М.К., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Деева Е.С., Исайкина М.А., Трушина О.Ю., Фомин В.В., Погонин А.В., Тамкаева М.К.</copyright-holder><copyright-holder xml:lang="en">Deeva E.S., Isaikina M.A., Trushina O.I., Fomin V.V., Pogonin A.V., Tamkaeva M.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.heartj.asia/jour/article/view/6490">https://www.heartj.asia/jour/article/view/6490</self-uri><abstract><p>Сердечно-сосудистые заболевания по-прежнему являются основной причиной смерти, как в развитых, так и в развивающихся странах. Ацетилсалициловая кислота в малых дозах используется во всем мире для первичной и вторичной профилактики сердечно-сосудистых событий на долгосрочной основе с целью снижения смертности и летальности. В то же время, частота гастродуоденальных кровотечений, связанных с приемом ацетилсалициловой кислоты, неуклонно растет. Приведенный клинический случай иллюстрирует развитие желудочно-кишечного кровотечения на фоне приема двойной антиагрегантной терапии у пациента с ишемической болезнью сердца с отягощенным язвенным анамнезом. Пациент, 65 лет, с отягощенным коронарным анамнезом был планово госпитализирован в кардиологическое отделение. При поступлении в стационар, учитывая нарастающие жалобы на давящие боли за грудиной, у пациента был исключен острый коронарный синдром, выполнена эзофагогастродуоденоскопия, по результатам которой выявлена каллезная язва субкардии. В тот же день отмечалась отрицательная динамика по клиническим проявлениям в виде синкопального состояния, гипотонии до 70/50 мм рт. ст., появления рвоты «кофейной гущей». По данным повторной экстренной эзофагогастродуоденоскопии выявлен поверхностный язвенный дефект в области субкардии с кровоточащим сосудом в дне и проведен комбинированный эндоскопический гемостаз. При дальнейшем обследовании пациента была выявлена инфицированность Helicobacter pylori, что в совокупности с другими факторами риска повлияло на возникновение данного осложнения. Была назначена противоязвенная эрадикационная терапия первой линии. На фоне проводимого комплексного лечения в дальнейшем субъективно своё состояние пациент оценивал как удовлетворительное, был выписан с рекомендациями на амбулаторное лечение. Цель данного клинического случая – подчеркнуть важность своевременного выявления и лечения заболеваний желудочно-кишечного тракта у пациентов высокого риска. Это может позволить в дальнейшем проводить своевременную профилактику развития кровотечений у пациентов с ишемической болезнью сердца высокого риска с учетом персонализированного подхода.</p></abstract><trans-abstract xml:lang="en"><p>Cardiovascular disease continues to be the leading cause of death in both developed and developing countries. Low-dose acetylsalicylic acid is used worldwide for primary and secondary prevention of cardiovascular events on a long-term basis to reduce mortality and lethality. At the same time, the incidence of gastrointestinal bleeding associated with acetylsalicylic acid intake is steadily increasing. The presented case report illustrates the development of gastrointestinal bleeding against the background of dual antiplatelet therapy in a patient with coronary heart disease with a history of ulcers. A 65-year-old patient with an aggravated coronary history was routinely hospitalized in the cardiology department. On admission to the hospital, taking into account the increasing complaints of crushing pain behind the sternum, acute coronary syndrome was excluded in the patient, esophagogastroduodenoscopy was performed, which revealed a subcardia callous ulcer. On the same day, there was a negative trend in clinical manifestations in the form of syncope, hypotension up to 70/50 mmHg, vomiting «coffee grounds». According to the data of repeated emergency esophagogastroduodenoscopy a superficial ulcerous defect in the subcardia area with bleeding vessel in the bottom was revealed and combined endoscopic hemostasis was performed. Further examination of the patient revealed Helicobacter pylori infection, which in combination with other risk factors influenced the occurrence of this complication. First-line anti-ulcer eradication therapy was prescribed. The patient subjectively evaluated his condition as satisfactory and was discharged with recommendations for outpatient treatment. The purpose of this case report is to emphasize the importance of timely detection and treatment of gastrointestinal diseases in high-risk patients. This may allow for timely prevention of bleeding in patients with high-risk coronary heart disease in the future, taking into account a personalized approach.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>острый коронарный синдром</kwd><kwd>ишемическая болезнь сердца</kwd><kwd>желудочно-кишечное кровотечение</kwd><kwd>язвенная болезнь желудка</kwd><kwd>язвенная болезнь двенадцатиперстной кишки</kwd><kwd>Helicobacter pylori</kwd><kwd>чрескожное коронарное вмешательство</kwd><kwd>факторы риска</kwd><kwd>прогноз</kwd><kwd>терапия</kwd><kwd>клинический случай</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute coronary syndrome</kwd><kwd>ischemic heart disease</kwd><kwd>gastrointestinal bleeding</kwd><kwd>gastric ulcer</kwd><kwd>duodenal ulcer</kwd><kwd>Helicobacter pylori</kwd><kwd>percutaneous coronary intervention</kwd><kwd>risk factors</kwd><kwd>prognosis</kwd><kwd>therapy</kwd><kwd>case report</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ежов М.В., Кухарчук В.В., Сергиенко И.В., Алиева А.С., Анциферов М.Б., Аншелес А.А., Арабидзе Г.Г., Аронов Д.М., Арутюнов Г.П., Ахмеджанов Н.М., Балахонова Т.В., Барбараш О.Л., Бойцов С.А., Бубнова М.Г., Воевода М.И., Галстян Г.Р., Галявич А.С., Горнякова Н.Б., Гуревич В.С., Дедов И.И., Драпкина О.М., Дупляков Д.В., Ерегин С.Я., Ершова А.И., Иртюга О.Б., Карпов С.Р., Карпов Ю.А., Качковский М.А., Кобалава Ж.Д., Козиолова Н.А., Коновалов Г.А., Константинов В.О., Космачева Е.Д., Котовская Ю.В., Мартынов А.И., Мешков А.Н., Небиеридзе Д.В., Недогода С.В., Обрезан А.Г., Олейников В.Э., Покровский С.Н., Рагино Ю.И., Ротарь О.П., Скибицкий В.В., Смоленская О.Г., Соколов А.А., Сумароков А.Б., Филиппов А.Е., Халимов Ю.Ш., Чазова И.Е., Шапошник И.И., Шестакова М.В., Якушин С.С., Шляхто Е.В. 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