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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">evrazkar</journal-id><journal-title-group><journal-title xml:lang="ru">Евразийский Кардиологический Журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Eurasian heart journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2225-1685</issn><issn pub-type="epub">2305-0748</issn><publisher><publisher-name>Евразийская ассоциация кардиологов</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.38109/2225-1685-2023-4-84-88</article-id><article-id custom-type="elpub" pub-id-type="custom">evrazkar-6430</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЙ СЛУЧАЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASE</subject></subj-group></article-categories><title-group><article-title>Клинический случай повторной тромболитической терапии острого циркулярно-верхушечного инфаркта миокарда, осложнённого ангинозным статусом</article-title><trans-title-group xml:lang="en"><trans-title>Case report of repeat thrombolytic therapy in patient with acute circular-apical myocardial infarction, complicated anginous status</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7558-8967</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Босиков</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bosikov</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Босиков Дмитрий Владиславович, врач анестезиолог-реаниматолог, отделение неотложной кардиологии</p><p>д.1, г. Мирный 678170, Республика Саха (Якутия)</p></bio><bio xml:lang="en"><p>Dmitry V. Bosikov, anesthesiologist intensive cardiac care unit, department of emergency cardiology</p><p>st. Pavlova, 1, Mirny 678170</p></bio><email xlink:type="simple">dishifrator@yahoo.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-5046-8541</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Степанова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Stepanova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Степанова Наталья Валентиновна, врач кардиолог, заведующая отделением неотложной кардиологии</p><p>д.1, г. Мирный 678170, Республика Саха (Якутия)</p></bio><bio xml:lang="en"><p>Natalya V. Stepanova, cardiologist, cardiac care unit chief</p><p>st. Pavlova, 1, Mirny 678170</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-1838-9813</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тарасова</surname><given-names>В. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Tarasova</surname><given-names>V. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тарасова Вера Евстафьевна, врач кардиолог, главный врач</p><p>д.1, г. Мирный 678170, Республика Саха (Якутия)</p></bio><bio xml:lang="en"><p>Vera E. Tarasova, cardiologist, Head of medical clinic</p><p>st. Pavlova, 1, Mirny 678170</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-7353-1628</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ботнарь</surname><given-names>Ю. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Botnar</surname><given-names>Yu.  M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ботнарь Юрий Михайлович, д.м.н., специалист по организации оказания медицинской помощи, Управление по реализации задач НМИЦ в субъектах РФ</p><p>ул. ак. Чазова, д. 15 а, г. Москва 121552</p></bio><bio xml:lang="en"><p>Yuri M. Botnar, Dr. of Sci. (Med.), specialist in the organization of health care, Department implementation of tasks SMRC in region Russian Federation, National Medical Research Center in the constituent entities of the Russian Federation</p><p>st. ak. Chazova, 15 a, Moscow 121552</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУ Республики Саха (Якутия) «Мирнинская ЦРБ»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Mirny Central District Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ «НМИЦ кардиологии им. ак. Е.И. Чазова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>E.I. Chazov National Medical Research Center of Cardiology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>22</day><month>11</month><year>2023</year></pub-date><volume>0</volume><issue>4</issue><fpage>84</fpage><lpage>88</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Босиков Д.В., Степанова Н.В., Тарасова В.Е., Ботнарь Ю.М., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Босиков Д.В., Степанова Н.В., Тарасова В.Е., Ботнарь Ю.М.</copyright-holder><copyright-holder xml:lang="en">Bosikov D.V., Stepanova N.V., Tarasova V.E., Botnar Y.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.heartj.asia/jour/article/view/6430">https://www.heartj.asia/jour/article/view/6430</self-uri><abstract><p>Приведенный клинический случай иллюстрирует нестандартный подход в виде повторного проведения тромболитической терапии пациенту 49 лет c острым циркулярно-верхушечным инфарктом миокарда после отсутствия эффекта от проведенной системной тромболитической терапии рекомбинантным активатором плазминогена. Спустя 90 минут после завершения процедуры введения фибринолитика была отмечена отрицательная динамика по ЭКГ в виде дополнительной элевации сегмента ST в ранее интактных отведениях, а также отрицательная динамика по клиническим проявлениям в виде рецидива ангинозных болей, рефрактерных к стандартным дозам наркотических анальгетиков. В связи с удаленностью ЧКВ-центра прогнозировалась существенная временная задержка механической реперфузии миокарда. Принимая во внимание совокупность представленных факторов, высокий риск развития неблагоприятного исхода, особенность клинического течения заболевания в виде рефрактерной ангинозной боли, было принято решение о проведении повторной системной тромболитической терапии неиммуногенной стафилокиназой, которая оказалась эффективной. В дальнейшем заболевание протекало без осложнений. ЧКВ выполнено спустя 28 часов с момента установления диагноза ОКС с подъемом сегмента ST: произведена транслюминальная балонная ангиопластика со стентированием средней трети ПНА.</p></abstract><trans-abstract xml:lang="en"><p>Presented clinical case report illustrates nonstandart approach use repeat thrombolytic therapy patient 49 y.o. with acute circular – apical myocardial infarction, after noneffective primary systemic thrombolytic therapy rtPA. Moreover, repeat thrombolytic therapy in hospital stage was vital alternative in case with significant tamely delay mechanical reperfusion. After 90 minutes then introduction rtPA has been done, we got negative dynamic on ECG in the form of additional ST-segment elevation at other (early intact) lead, and reccurent anginous pain refractory to standard doses narcotic analgesic. In connection with remote PCI – center, we supposed significant tamely deIlay to mechanical reperfusion. In view of this factors, high risk to undesired event, refractory anginous pain, we made decision of repeat thrombolytic therapy with non-immunogenic staphilokinase, and it has been effective. At a later time the disease is taking it’s normal course.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>повторная тромболитическая терапия</kwd><kwd>неиммуногенная стафилокиназа</kwd><kwd>алтеплаза</kwd><kwd>окклюзия ПНА</kwd><kwd>рефрактерный ангинозный приступ</kwd><kwd>клинический случай</kwd></kwd-group><kwd-group xml:lang="en"><kwd>idiorepeat thrombolytic therapy</kwd><kwd>non-immunogenic staphilokinase</kwd><kwd>alteplase</kwd><kwd>occlusion LAD</kwd><kwd>refractory anginous pain</kwd><kwd>case report</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Статья подготовлена при финансовой поддержке компании ООО «СупраГен».</funding-statement><funding-statement xml:lang="en">The article was prepared with the financial support of SupraGen LLC.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Данные Росстата на 22.06.2019. 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