evrazkarЕвразийский Кардиологический ЖурналEurasian heart journal2225-16852305-0748Евразийская ассоциация кардиологов10.38109/2225-1685-2023-4-64-68evrazkar-6427Research ArticleОБЗОРREVIEWПолиморфизм rs1143634 гена интерлейкина-1β и кардиоваскулярные осложнения у пациентов с атеросклерозом коронарных артерийInterleukin-1β gene rs1143634 polymorphism and cardiovascular complications in patients with coronary artery atherosclerosishttps://orcid.org/0000-0001-8050-2892ХазоваЕ. В.KhazovaE. V.

Хазова Елена Владимировна, к.м.н., доцент, кафедра пропедевтики внутренних болезней им. профессора С.С. Зимницкого

ул. Бутлерова, д. 49, каб. 212, г. Казань 420012

Elena V. Khazova, Cand. of Sci. (Med)., associate professor, the department of propaedeutics of internal diseases named after Professor SS. Zimnitsky

Butlerov str., 49, Kazan 420012

hazova_elena@mail.ruhttps://orcid.org/0000-0002-7228-5848БулашоваО. В.BulashovaO. V.

Булашова Ольга Васильевна, д.м.н., профессор, кафедра пропедевтики внутренних болезней им. профессора С.С. Зимницкого

ул. Бутлерова, д. 49, каб. 212, г. Казань 420012

Olga V. Bulashova, Dr. of Sci. (Med.), Professor, the department of propaedeutics of internal diseases named after Professor SS. Zimnitsky

Butlerov str., 49, Kazan 420012

boulashova@yandex.ruhttps://orcid.org/0000-0001-7080-3878ВалееваЕ. В.ValeevaE. V.

Валеева Елена Валерьевна, к.б.н., старший научный сотрудник, центральная научно-исследовательская лаборатория

ул. Бутлерова, д. 49, каб. 212, г. Казань 420012

Elena V. Valeeva, Cand. of Sci. (Biol.), Senior Researcher, the Central Research Laboratory

Butlerov str., 49, Kazan 420012

vevaleeva@ya.ruФГБОУ ВО «Казанский ГМУ»РоссияKazan State Medical UniversityRussian Federation202322112023046468Copyright © Хазова Е.В., Булашова О.В., Валеева Е.В., 20232023Хазова Е.В., Булашова О.В., Валеева Е.В.Khazova E.V., Bulashova O.V., Valeeva E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.heartj.asia/jour/article/view/6427

Течение сердечной недостаточности, независимо от ее этиологии, сопряжено с локальной и системной активацией воспалительных сигнальных каскадов. Изучение ассоциации полиморфизма генов-кандидатов, кодирующих синтез цитокинов с риском развития ишемической болезни сердца и хронической сердечной недостаточности остается предметом интереса многих исследователей. В обзоре представлен анализ исследований полиморфизма rs1143634 гена IL-β во взаимосвязи с риском возникновения атеросклеротических кардиоваскулярных осложнений. Наличие минорного аллеля Т связано с повышением концентрации IL-1β в сыворотке крови. Приведены данные о роли полиморфизма rs1143634 гена IL-β при ишемической болезни сердца, в том числе в сочетании с синдромом хронической сердечной недостаточности с учетом этнических особенностей и пола пациентов. Носительство аллеля Т ассоциировалось с риском развития атеросклероза, инфаркта миокарда. Установлено, что фактором генетического риска развития и прогрессирования сердечной недостаточности может быть аллель С и генотип СС полиморфизма rs1143634 гена IL-1β. В ряде исследований и метаанализов связь данного полиморфизма с заболеваниями сердечно-сосудистой системы не была подтверждена, но были выявлены определённые траектории риска кардиоваскулярных осложнений в связи с различиями полиморфизма rs1143634 гена IL-β при сердечной недостаточности.

The course of heart failure, regardless of its etiology, is associated with local and systemic activation of inflammatory signaling cascades. Identification of the association of candidate cytokine genes with the risk of developing coronary heart disease and chronic heart failure remains a subject of interest for many researchers. The review presents an analysis of studies of the rs1143634 polymorphism of the IL-β gene in relation to the risk of atherosclerotic cardiovascular complications. The presence of the minor allele T is associated with an increase in the concentration of IL-1β in the blood serum. Data on the role of the rs1143634 polymorphism of the IL-β gene in atherosclerotic coronary heart disease, including in combination with chronic heart failure syndrome, are presented, taking into account ethnic characteristics and gender of patients. The carriage of the T allele was associated with the risk of developing atherosclerosis and myocardial infarction. At the same time, it is reported that the C allele and the CC genotype of the rs1143634 polymorphism of the IL-1β gene were a genetic risk factor for the development and progression of heart failure. In a number of studies and meta-analyses, the association of this polymorphism with diseases of the cardiovascular system was not confirmed, but certain trajectories of the risk of complications were identified due to differences in the rs1143634 polymorphism of the IL-β gene in heart failure.

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The authors declare that there are no conflicts of interest present.