evrazkarЕвразийский Кардиологический ЖурналEurasian heart journal2225-16852305-0748Евразийская ассоциация кардиологов10.38109/2225-1685-2021-2-92-102evrazkar-6271Research ArticleМНЕНИЕ ЭКСПЕРТАEXPERT OPINIONПРИМЕНЕНИЕ КОМБИНИРОВАННЫХ ПРЕПАРАТОВ С ПОСТОЯННЫМИ ДОЗАМИ АНТИГИПЕРТЕНЗИВНЫХ СРЕДСТВ КАК НАЧАЛЬНАЯ ТАКТИКА ЛЕЧЕНИЯ ПРИ ПОВЫШЕННОМ УРОВНЕ АРТЕРИАЛЬНОГО ДАВЛЕНИЯ: ДОКАЗАННЫЕ ФАКТЫ И МНЕНИЕ ЭКСПЕРТОВTHE APPLICATION OF COMBINED PREPARATIONS WITH CONSTANT DOSES OF ANTIHYPERTENSIVE DRUGS AS THE INITIAL TACTICS OF TREATMENT AT HIGH BLOOD PRESSURE LEVEL: PROVEN FACTS AND EXPERT’S OPINIONhttps://orcid.org/0000-0002-8505-1848ГиляревскийС. Р.GilyarevskijS. R.

 д.м.н., профессор, профессор группы по разработке и реализации профильных образовательных программ отдела  организационно-методического управления и анализа качества медицинской помощи; профессор кафедры клинической  фармакологии и терапии

+7(495)945-70-90

101990, г. Москва, Петроверигский Пер., 10, стр. 3

125993, г. Москва, ул. Баррикадная, д. 2/1, стр. 1 

 Dr. of Sci. (Med.), Professor of the group for the development and implementation of specific educational programmes of the Department of Organizational and Methodological Management and Analysis of the Quality of Medical Care; Professor of the Department of Clinical  Pharmacology and Therapy

Tel. +7(495)945-70-90 

101990, Moscow, Petroverigsky Per., 10, P. 3

125993, Moscow, St. Barrikadnaya, 2/1, Building 1

sgilarevsky@rambler.ruhttps://orcid.org/0000-0003-3102-1958БенделианиН. Г.BendelianiN. G.

 д.м.н., старший научный сотрудник научно-консультативного отделения института коронарной и сосудистой хирургии (ИКиСХ) консультативно-диагностического центра (КДЦ) 

121552, Москва, Рублевское Шоссе, Д. 135

 Dr. of Sci. (Med.), Senior Researcher of Scientific Advisory Department 

 121552, Moscow, Rublevskoe Highway, 135

n.bendo@mail.ruhttps://orcid.org/0000-0002-9865-4998ГолшмидМ. В.GolshmidM. V.

 к.м.н., доцент кафедры клинической фармакологии и терапии 

125993, Г. Москва, Ул. Баррикадная, Д. 2/1, Стр. 1

 Cand. of Sci. (Med.), Associate Professor of the Department of Clinical Pharmacology and Therapy 

125993, Moscow, St. Barrikadnaya, 2/1, Building 1

golshmid@yandex.ruhttps://orcid.org/0000-0001-9458-7305КузьминаИ. М.Kuz’minaI. M.

 к.м.н., заведующий научным отделением неотложной кардиологии 

129010, Россия, г. Москва, Большая Сухаревская Площадь, д. 3

 Cand. Med. Sci., Leading Researcher, Department of Emergency Cardiology 

 129010, Russia, Moscow, Bolshaya Sukharevskaya Square, 3

kuzmina.sklif@gmail.comАндрееваИ. Г.AndreevaI. G.

 д.м.н., профессор кафедры педагогики и психологии

105082, Москва, Ул. Фридриха Энгельса, Д.75, Строение 3 

 Dr. of Sci. (Med.), Professor of Department of Pedagogics and Psychology 

105082, Moscow, St. Friedrich Engels, 75, Building 3

andreevaira@mail.ruФГБУ «НМИЦ ТПМ» Минздрава России; РМАНПО Минздрава РоссииРоссияNational Medical Research Center For Therapy And Preventive Medicine Of The Ministry Of Health Of Russia; Russian Medical Academy Of Continuing Professional Education Of The Ministry Of Health Of RussiaRussian FederationФГБУ «Национальный медицинский исследовательский центр сердечно-сосудистой хирургии имени А.Н. Бакулева» Министерство здравоохранения РФФГБУ «НМИЦССХ им. А.Н. Бакулева» Минздрава РоссииРоссияInstitute Of Coronary And Vascular Surgery, Consultative And Diagnostic Center, A.N. Bakulev NMRCCVS Of The Ministry Of Health Of Russian FederationRussian FederationРМАНПО Минздрава РоссииРоссияRussian Medical Academy Of Continuing Professional Education Of The Ministry Of Health Of RussiaRussian FederationГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»РоссияN.V. Sklifosovsky Research Institute For Emergency MedicineRussian FederationМосковский Социально-Педагогического ИнститутРоссияMoscow Social Pedagogical Institute,Russian Federation2021290520210292102Copyright © Гиляревский С.Р., Бенделиани Н.Г., Голшмид М.В., Кузьмина И.М., Андреева И.Г., 20212021Гиляревский С.Р., Бенделиани Н.Г., Голшмид М.В., Кузьмина И.М., Андреева И.Г.Gilyarevskij S.R., Bendeliani N.G., Golshmid M.V., Kuz’mina I.M., Andreeva I.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.heartj.asia/jour/article/view/6271

 В статье обсуждаются современные проблемы применения комбинированных антигипертензивных препаратов при реализации «тактики одной таблетки» у широкого круга пациентов с артериальной гипертонией. Приводятся  результаты обсуждения такой проблемы экспертами, а  также основные положения согласительного документа, посвященного подходам к реализации тактики более  широкого использования комбинированных  антигипертензивных препаратов, содержащих в одной  таблетке 2 антигипертензивных средства или более.  Рассматриваются как преимущества, так и ограничения  «тактики одной таблетки». Обсуждаются результаты клинических исследований, которые подтверждают  обоснованность использования комбинированной  антигипертензивной терапии в качестве начальной тактики  лечения большинства пациентов с артериальной  гипертонией. Приводятся результаты оценки фармакоэкономических показателей при использовании комбинированной антигипертензивной терапии.  

 In this article the current problems of the use of combined antihypertensive drugs in the implementation of «tactics one tablet» in a wide range of patients with arterial hypertension are discussed. The results of the discussion of such a problem by experts, as well as the main provisions of the agreement document, are given, devoted to approaches to the implementation of tactics of wider use of combined antihypertensive drugs containing 2 or more antihypertensive drugs in one tablet. Both the advantages and disadvantages of «tactics one tablet « are considered. The results of clinical studies are discussed, which confirm the validity of the use of the combined antihypertensive therapy as an initial tactic of treatment of the majority of patients with arterial hypertension. The results of the assessment of pharmacoeconomic indicators are given when using combined antihypertensive therapy. 

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The authors declare that there are no conflicts of interest present.