One of the most important medical and social problems are acute cerebrovascular disorders, among which the most part is ischemic stroke. Known that in the development of stroke leading role belongs to endothelial dysfunction (ED), the main manifestation of which is the metabolic changes of the vascular wall, the release of a significant amount endothelin-1 (EDN1) and the development of vasoconstriction. Therefore, one of the candidate genes, polymorphisms that can be associated with a predisposition to the development of ED and consequently contribute to stroke, is EDN1 gene. In order to improve the prevention of stroke, we decided carry out a study among healthy persons and identify possible susceptibility. The aim of our study was to analyze the association Lys198Asn polymorphism of EDN1 gene with ischemic atherothrombotic stroke (IAS) risk factors in the Ukrainian population.