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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">evrazkar</journal-id><journal-title-group><journal-title xml:lang="ru">Евразийский Кардиологический Журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Eurasian heart journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2225-1685</issn><issn pub-type="epub">2305-0748</issn><publisher><publisher-name>Евразийская ассоциация кардиологов</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.38109/2225-1685-2013-1-19-30</article-id><article-id custom-type="elpub" pub-id-type="custom">evrazkar-5536</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL PAPERS</subject></subj-group></article-categories><title-group><article-title>КОМБИНИРОВАННАЯ ТЕРАПИЯ АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИИ - НАШИ ОЖИДАНИЯ</article-title><trans-title-group xml:lang="en"><trans-title>COMBINATION THERAPY OF ARTERIAL HYPERTENSION - OUR EXPECTATIONS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Остроумова</surname><given-names>Ольга Дмитриевна</given-names></name><name name-style="western" xml:lang="en"><surname>Ostroumova</surname><given-names>O. D.</given-names></name></name-alternatives><email xlink:type="simple">ostroumova.olga@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гусева</surname><given-names>Татьяна Федоровна</given-names></name><name name-style="western" xml:lang="en"><surname>Guseva</surname><given-names>T. F.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский государственный медико-стоматологический университет им. А.И. Евдокимова; Первый московский государственный медицинский университет им. И. М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow State Medical and Dental University of A.I. Evdokimov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Московский государственный медико-стоматологический университет им. А.И. Евдокимова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow State Medical and Dental University of A.I. Evdokimov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>30</day><month>03</month><year>2013</year></pub-date><volume>0</volume><issue>1</issue><fpage>19</fpage><lpage>30</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Остроумова О.Д., Гусева Т.Ф., 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Остроумова О.Д., Гусева Т.Ф.</copyright-holder><copyright-holder xml:lang="en">Ostroumova O.D., Guseva T.F.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.heartj.asia/jour/article/view/5536">https://www.heartj.asia/jour/article/view/5536</self-uri><abstract><p>В статье рассматриваются различные аспекты комбинированной терапии артериальной гипертонии. Приведены взаимодополняющие эффекты и преимущества комбинации блокаторов рецепторов к ангиотензину II и антагонистов кальция, описаны клинические ситуации, где ее использование является приоритетным. Подробно проанализированы имеющиеся литературные данные об эффективности и безопасности фиксированной комбинации телмисартана с амлодипином, в том числе у больных с ожирением, сахарным диабетом, тяжелой артериальной гипертонией.</p></abstract><trans-abstract xml:lang="en"><p>The article is devoted to various aspects of the combined therapy of arterial hypertension. Given the complementary effects and advantages of the combination blockers receptors to angiotenzin II and calcium antagonists, are described clinical situation, where its use is a priority. Analyzed in detail the available literature data on the efficacy and safety of fixed combination telmisartan with amlodipine, including in patients with obesity, diabetes, severe arterial hypertension.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>arterial hypertension</kwd><kwd>fixed combinations</kwd><kwd>angiotensin receptor blockers II</kwd><kwd>telmisartan</kwd><kwd>calcium antagonists</kwd><kwd>amlodipine</kwd><kwd>артериальная гипертония</kwd><kwd>фиксированные комбинации</kwd><kwd>блокаторы рецепторов к ангиотензину II</kwd><kwd>телмисартан</kwd><kwd>антагонисты кальция</kwd><kwd>амлодипин</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Диагностика и лечение артериальной гипертензии. Системные гипертензии 2010; 3: 5-26.</mixed-citation><mixed-citation xml:lang="en">Диагностика и лечение артериальной гипертензии. Системные гипертензии 2010; 3: 5-26.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Кукес В.Г., Остроумова О.Д., Стародубцев А.К. Антагонисты кальция: современные аспекты применения в кардиологии. Consilium medicum, 2006; Том 8 (№ 11): 113-117.</mixed-citation><mixed-citation xml:lang="en">Кукес В.Г., Остроумова О.Д., Стародубцев А.К. Антагонисты кальция: современные аспекты применения в кардиологии. Consilium medicum, 2006; Том 8 (№ 11): 113-117.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Dahlof B., Sever P.S., Poulter N.R. et al. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005; 366: 895906.</mixed-citation><mixed-citation xml:lang="en">Dahlof B., Sever P.S., Poulter N.R. et al. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005; 366: 895906.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Jamerson K., Weber M.A., Bakris G.L., et al. Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients. N Engl J Med 2008; 359: 2417-28.</mixed-citation><mixed-citation xml:lang="en">Jamerson K., Weber M.A., Bakris G.L., et al. Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients. N Engl J Med 2008; 359: 2417-28.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Reboldi G., Angeli F., Cavallini C., et al. Comparison between angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on the risk of myocardial infarction, stroke and death: a meta-analysis. J Hypertens 2008; 26: 1282-9.</mixed-citation><mixed-citation xml:lang="en">Reboldi G., Angeli F., Cavallini C., et al. Comparison between angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on the risk of myocardial infarction, stroke and death: a meta-analysis. J Hypertens 2008; 26: 1282-9.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Matchar D.B., Mccrory D.C., Orlando L.A., et al. Systematic review: comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for treating essential hypertension. Ann Intern Med 2008; 148: 16-29.</mixed-citation><mixed-citation xml:lang="en">Matchar D.B., Mccrory D.C., Orlando L.A., et al. Systematic review: comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for treating essential hypertension. Ann Intern Med 2008; 148: 16-29.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Mistry N.B., Westheim A.S., Kjeldsen S.E. The angiotensin receptor antagonist valsartan: a review of the literature with a focus on clinical trials. Expert Opin Pharmacother. 2006; 7: 575-581.</mixed-citation><mixed-citation xml:lang="en">Mistry N.B., Westheim A.S., Kjeldsen S.E. The angiotensin receptor antagonist valsartan: a review of the literature with a focus on clinical trials. Expert Opin Pharmacother. 2006; 7: 575-581.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Sica D.A. Rationale for fixed-dose combinations in the treatment of hypertension: the cycle repeats. Drugs. 2002; 62: 443-462.</mixed-citation><mixed-citation xml:lang="en">Sica D.A. Rationale for fixed-dose combinations in the treatment of hypertension: the cycle repeats. Drugs. 2002; 62: 443-462.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Quan A., Chavanu K., Merkel J. et al. A review of the efficacy of fixed-dose combinations olmesartan medoxomil/hydrochlorothiazide and amlodipine besylate/benazepril in factorial design studies. Am J Cardiovasc Drugs. 2006; 6: 103-113.</mixed-citation><mixed-citation xml:lang="en">Quan A., Chavanu K., Merkel J. et al. A review of the efficacy of fixed-dose combinations olmesartan medoxomil/hydrochlorothiazide and amlodipine besylate/benazepril in factorial design studies. Am J Cardiovasc Drugs. 2006; 6: 103-113.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Littlejohn T.W. III, Majul C.R., Olvera R. et al. Results of treatment with telmisartan-amlodipine in hypertensive patients. J Clin Hypertens. 2009: 11: 207-213.</mixed-citation><mixed-citation xml:lang="en">Littlejohn T.W. III, Majul C.R., Olvera R. et al. Results of treatment with telmisartan-amlodipine in hypertensive patients. J Clin Hypertens. 2009: 11: 207-213.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Littlejohn T.W. III, Majul C.R., Olvera R. et al. Telmisartan plus amlodipine in patients with moderate or severe hypertension: results from a post-hoc subgroup analysis of a randomized, placebo-controlled, parallel-group, 4 x 4 factorial study. Postgrad Med. 2009; 121: 5-14.</mixed-citation><mixed-citation xml:lang="en">Littlejohn T.W. III, Majul C.R., Olvera R. et al. Telmisartan plus amlodipine in patients with moderate or severe hypertension: results from a post-hoc subgroup analysis of a randomized, placebo-controlled, parallel-group, 4 x 4 factorial study. Postgrad Med. 2009; 121: 5-14.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Neldam S., Edwards C., Jones R. Switching patients with uncontrolled hypertension on amlodipine 10 mg to single-pill combinations of telmisartan and amlodipine: results of the TEAMSTA-10 study. Curr Med Res Opin 2011; 27: 2145-53.</mixed-citation><mixed-citation xml:lang="en">Neldam S., Edwards C., Jones R. Switching patients with uncontrolled hypertension on amlodipine 10 mg to single-pill combinations of telmisartan and amlodipine: results of the TEAMSTA-10 study. Curr Med Res Opin 2011; 27: 2145-53.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Neldam S., Edwards C., Lang M., Jones R. for The TEAMSTA-5 and TEAMSTA-10 Investigators. Long-Term Tolerability and Efficacy of SinglePill Combinations of Telmisartan 40-80 mg Plus Amlodipine 5 or 10 mg in Patients Whose Blood Pressure Was Not Initially Controlled by Amlodipine 5-10 mg: Open-Label, Long-Term Follow-Ups of the TEAMSTA-5 and TEAMSTA-10 Studies. Current Therapeutic Research, Clinical and Experimental 2012,73 (1/2): 65-84.</mixed-citation><mixed-citation xml:lang="en">Neldam S., Edwards C., Lang M., Jones R. for The TEAMSTA-5 and TEAMSTA-10 Investigators. Long-Term Tolerability and Efficacy of SinglePill Combinations of Telmisartan 40-80 mg Plus Amlodipine 5 or 10 mg in Patients Whose Blood Pressure Was Not Initially Controlled by Amlodipine 5-10 mg: Open-Label, Long-Term Follow-Ups of the TEAMSTA-5 and TEAMSTA-10 Studies. Current Therapeutic Research, Clinical and Experimental 2012,73 (1/2): 65-84.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Neutel J., Mancia G., Black H., et al. Single-Pill Combination of Telmisartan/Amlodipine in Patients With Severe Hypertension: Results From the TEAMSTA Severe HTN Study. Journal of Clinical Hypertension (Greenwich), 2012; 14 (4): 206 - 215 (ERRATUM The Journal of Clinical Hypertension doi: 10.1111/jch.12025).</mixed-citation><mixed-citation xml:lang="en">Neutel J., Mancia G., Black H., et al. Single-Pill Combination of Telmisartan/Amlodipine in Patients With Severe Hypertension: Results From the TEAMSTA Severe HTN Study. Journal of Clinical Hypertension (Greenwich), 2012; 14 (4): 206 - 215 (ERRATUM The Journal of Clinical Hypertension doi: 10.1111/jch.12025).</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma A.M., Bakris G., Neutel J.M., et al. Single-pill combination of telmisartan/amlodipine versus amlodipine monotherapy in diabetic hypertensive patients: an 8-week randomized, parallel-group, double-blind trial. Clin Ther. 2012; 34: 537-51.</mixed-citation><mixed-citation xml:lang="en">Sharma A.M., Bakris G., Neutel J.M., et al. Single-pill combination of telmisartan/amlodipine versus amlodipine monotherapy in diabetic hypertensive patients: an 8-week randomized, parallel-group, double-blind trial. Clin Ther. 2012; 34: 537-51.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Guthrie R.M., Dahlof B., Jamerson K.A., et al. Efficacy and tolerability of telmisartan plus amlodipine in added-risk hypertensive patients. Curr Med Res Opin 2011; 27: 1995-2008.</mixed-citation><mixed-citation xml:lang="en">Guthrie R.M., Dahlof B., Jamerson K.A., et al. Efficacy and tolerability of telmisartan plus amlodipine in added-risk hypertensive patients. Curr Med Res Opin 2011; 27: 1995-2008.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">White W.B., Littlejohn T.W., Majul C.R., et al. Effects of telmisartan and amlodipine in combination on ambulatory blood pressure in stages 1-2 hypertension. Blood Press Monit 2010; 15: 205-12.</mixed-citation><mixed-citation xml:lang="en">White W.B., Littlejohn T.W., Majul C.R., et al. Effects of telmisartan and amlodipine in combination on ambulatory blood pressure in stages 1-2 hypertension. Blood Press Monit 2010; 15: 205-12.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
