evrazkarЕвразийский Кардиологический ЖурналEurasian heart journal2225-16852305-0748Евразийская ассоциация кардиологов10.38109/2225-1685-2011-1-46-53evrazkar-5428Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL PAPERSСОВРЕМЕННЫЕ ВОЗМОЖНОСТИ ПЕРВИЧНОЙ ПРОФИЛАКТИКИ ВНЕЗАПНОЙ КОРОНАРНОЙ СМЕРТИ С ПОЗИЦИИ РАННЕЙ КОРРЕКЦИИ АКТИВНОСТИ НЕЙРОГУМОРАЛЬНЫХ СИСТЕМ У БОЛЬНЫХ ИНФАРКТОМ МИОКАРДАMODERN OPPORTUNITIES OF PRIMARY PROPHYLAXIS OF SUDDEN CORONARY DEATH FROM A POSITION OF EARLY CORRECTION OF ACTIVITY THE NEUROHORMONAL SYSTEMS AT PATIENTS WITH MYOCARDIAL INFARCTIONКурбановР. Д.KurbanovR. D.

Равшанбек Давлетович Курбанов

noemail@neicon.ruМуллабаеваГ. У.MullabaevaG. U.

Муллабаева Гузаль Учкуновна

Guzal-m@inbox.ruРеспубликанский Специализированный Центр КардиологииУзбекистанThe Republican Specialized Center of CardiologyUzbekistan201130032011014653Copyright © Курбанов Р.Д., Муллабаева Г.У., 20112011Курбанов Р.Д., Муллабаева Г.У.Kurbanov R.D., Mullabaeva G.U.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.heartj.asia/jour/article/view/5428

Статья посвящена первичной профилактике внезапной сердечной смерти путем воздействия на ренин-ангиотензин-альдостероновую и симпатоадреналовую системы. Приведены результаты многочисленных трайлов с использованием бета-блокаторов и ингибиторов ангиотензинпревращающего фермента. Обосновано как можно раннее использование этих групп препаратов у пациентов с острым инфарктом миокарда.

The article is devoted to primary prophylaxis of sudden cardiac death by influence on renninangiotensin-aldosterone and sympathetic systems. Results numerous trials with use beta-blockers, and ACE inhibitors are resulted. It is proved as early use of these groups of preparations at patients with myocardial infarction is possible.

ишемическая болезнь сердцавнезапная коронарная смертьсимпатоадреналовая и ренин-ангиотензин-альдостероновая системабета-блокаторыингибиторы АПФischemic heart diseasesudden coronary deathsympathetic and renin-angiotenzin aldosterone systembeta-blockersACE inhibitorsReferencesГолицын С.П. Лечение желудочковых аритмий с позиции первичной и вторичной профилактики внезапной смерти. // Сердечная недостаточность. - 2001. - Т. 2. - № 5. - С. 2 - 10.Голицын С.П. Лечение желудочковых аритмий с позиции первичной и вторичной профилактики внезапной смерти. // Сердечная недостаточность. - 2001. - Т. 2. - № 5. - С. 2 - 10.ACC/AHA Guidelines for the Management of Patients with ST-elevation Myocardial Infarction. A Report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction).ACC/AHA Guidelines for the Management of Patients with ST-elevation Myocardial Infarction. A Report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction).Borghi C., Bacchelli S., Esposti D.D. et al. SMILE Study. Effects of the early ACE inhibition in diabetic nontrombolyzed patients with anterior acute myocardial infarction // Diabetes Care. - 2003; 26 (6): 1862 - 1868.Borghi C., Bacchelli S., Esposti D.D. et al. SMILE Study. Effects of the early ACE inhibition in diabetic nontrombolyzed patients with anterior acute myocardial infarction // Diabetes Care. - 2003; 26 (6): 1862 - 1868.Brodsky M.A., Mitchell L.B., Halperin B.D.et al. Prognostic value of baseline electrophysiology studies in patients with sustained ventricular tachyarrhythmia: the Antiarrhythmics Versus Implantable Defibrillators (AVID) trial. //Am Heart J, 2002 Sep; 144(3):478-84.Brodsky M.A., Mitchell L.B., Halperin B.D.et al. Prognostic value of baseline electrophysiology studies in patients with sustained ventricular tachyarrhythmia: the Antiarrhythmics Versus Implantable Defibrillators (AVID) trial. //Am Heart J, 2002 Sep; 144(3):478-84.Chinese Cardiac Study Collaborative group. Oral Captopril versus placebo among 13634 patients with suspected acute myocardial infarction: interim report from the Chinese Cardiac Study (CCS-1). Lancet 1995; 345:686-687Chinese Cardiac Study Collaborative group. Oral Captopril versus placebo among 13634 patients with suspected acute myocardial infarction: interim report from the Chinese Cardiac Study (CCS-1). Lancet 1995; 345:686-687Cohn J., Levine T.B., Olivari H.T. et al. Ejection fraction, exercise consumption, cardiothoracic ration, ventricular arrhythmias, and plasma norepinephrine as determinants of prognosis in heart failure. Circulation 1993; 87: V115 - V116.Cohn J., Levine T.B., Olivari H.T. et al. Ejection fraction, exercise consumption, cardiothoracic ration, ventricular arrhythmias, and plasma norepinephrine as determinants of prognosis in heart failure. Circulation 1993; 87: V115 - V116.Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. The Acute Infarction Ramipril Efficacy (AIRE) Study Investigators//Lancet. 1993 Oct 2; 342 (8875): 821 - 828Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. The Acute Infarction Ramipril Efficacy (AIRE) Study Investigators//Lancet. 1993 Oct 2; 342 (8875): 821 - 828Ellison K.E., Hafley G.E., Hickey K.et al. Effect of beta-blocking therapy on outcome in the Multicenter UnSustained Tachycardia Trial (MUSTT). // Circulation, 2002 Nov 19; 106(21):2694-9Ellison K.E., Hafley G.E., Hickey K.et al. Effect of beta-blocking therapy on outcome in the Multicenter UnSustained Tachycardia Trial (MUSTT). // Circulation, 2002 Nov 19; 106(21):2694-9Fletcher R.D., Cintron G.B., Johnson G. et.al. Enalapril decreases prevalence of ventricular tachycardia in patients with chronic congestive failure. Circulation 1993; 87:6:V149 - V155Fletcher R.D., Cintron G.B., Johnson G. et.al. Enalapril decreases prevalence of ventricular tachycardia in patients with chronic congestive failure. Circulation 1993; 87:6:V149 - V155Francis G.S., Cohn J.N., Johnson G. et al. Plasma norepinephrine, rennin activity and congestive heart failure: relations to survival and the effects of therapy in V-HeFT-II. Icid. 1993; 87 (suppl. VI): V140 - V148.Francis G.S., Cohn J.N., Johnson G. et al. Plasma norepinephrine, rennin activity and congestive heart failure: relations to survival and the effects of therapy in V-HeFT-II. Icid. 1993; 87 (suppl. VI): V140 - V148.Greene L.N. Interactions between pharmacologic and nonpharmacologic antiarrhythmic therapy. // Am. J. Cardiol. - 1996. - Vol. 78 (suppl 4 A). - P 61 -66.Greene L.N. Interactions between pharmacologic and nonpharmacologic antiarrhythmic therapy. // Am. J. Cardiol. - 1996. - Vol. 78 (suppl 4 A). - P 61 -66.Gruppo Italiano per lo Studio della Sopravvivenza nel' Infarto miocardico-3. GISSI - 3: Effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after myocardial infarction. Lancet 1994:343:1115 - 1122Gruppo Italiano per lo Studio della Sopravvivenza nel' Infarto miocardico-3. GISSI - 3: Effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after myocardial infarction. Lancet 1994:343:1115 - 1122Halawa B. Antiarrhythmic agents in the prevention of sudden cardiac death. // Pol Merkuriusz Lek, 1999 Mar; 6:117-20.Halawa B. Antiarrhythmic agents in the prevention of sudden cardiac death. // Pol Merkuriusz Lek, 1999 Mar; 6:117-20.Hilleman D.E., Bauman A.L. Role of antiarrhythmic therapy in patients at risk for sudden cardiac death: an evidence-based review. // Pharmacotherapy, 2001 May; 21 (5): 556-75.Hilleman D.E., Bauman A.L. Role of antiarrhythmic therapy in patients at risk for sudden cardiac death: an evidence-based review. // Pharmacotherapy, 2001 May; 21 (5): 556-75.ISIS-4 Collaborative Group. ISIS-4: a randomized factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58050 patients with suspected myocardial infarction. Lancet 1995; 345:669 - 685ISIS-4 Collaborative Group. ISIS-4: a randomized factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58050 patients with suspected myocardial infarction. Lancet 1995; 345:669 - 685K ber L, Torp-Pedersen C, Carlsen J.E., Bagger H., Eliasen P., Lyngborg K., VidebaekJ., Cole D.S., Auclert L., Pauly N.C. A clinical trial of the angiotenzin-converting-enzyme inhibitor trandolapril in patients with left ventricular dysfunction after myocardial infarction. Trandolapril Cardiac Evaluation (TRACE) Study Group // N Engl J Med. 1995; 333: 1670-1676K ber L, Torp-Pedersen C, Carlsen J.E., Bagger H., Eliasen P., Lyngborg K., VidebaekJ., Cole D.S., Auclert L., Pauly N.C. A clinical trial of the angiotenzin-converting-enzyme inhibitor trandolapril in patients with left ventricular dysfunction after myocardial infarction. Trandolapril Cardiac Evaluation (TRACE) Study Group // N Engl J Med. 1995; 333: 1670-1676Masson S., Sesse F., Latini R. et al. Neuroendocrine variability in patients with heart failure. In: 13th World Congress of Cardiology. Rio de Janeiro; 1998. Abstr. 1148.Masson S., Sesse F., Latini R. et al. Neuroendocrine variability in patients with heart failure. In: 13th World Congress of Cardiology. Rio de Janeiro; 1998. Abstr. 1148.Naccarelli G.V., Wolbrette D.L., Patel H.M., Luck J.C. Amiodarone: clinical trials. /Curr. Opin. Cardiol. -2000. - 16:64 - 72.Naccarelli G.V., Wolbrette D.L., Patel H.M., Luck J.C. Amiodarone: clinical trials. /Curr. Opin. Cardiol. -2000. - 16:64 - 72.Podrid P.J., Fuchs T., Candinas R. Role of the sympathetic nervous system in the genesis of ventricular arrhythmia. Circulation 1990; 82:8:1103 - 1113.Podrid P.J., Fuchs T., Candinas R. Role of the sympathetic nervous system in the genesis of ventricular arrhythmia. Circulation 1990; 82:8:1103 - 1113.Rashba E.J., Cooklin M., MacMurdy K.et al. Effects of selective autonomic blockade on T-wave alternans in humans. // Circulation, 2002 Feb 19; 105 (7): 837-42.Rashba E.J., Cooklin M., MacMurdy K.et al. Effects of selective autonomic blockade on T-wave alternans in humans. // Circulation, 2002 Feb 19; 105 (7): 837-42.Santini M., Cacciatore G., Ansalone G. Heart failure and arrhythmias: the role of ACE inhibitors. Ann Ital Med Int 1993; 8:10S - 13S.Santini M., Cacciatore G., Ansalone G. Heart failure and arrhythmias: the role of ACE inhibitors. Ann Ital Med Int 1993; 8:10S - 13S.Swedberg K., Held P., Kjekhus J. et al. for the CONSENSUS II study group. Effects of an early administration of enalapril on mortality in patients with myocardial infarction. Results of the Cooperative New Scandinavian Enalapril Survival Study II. New Engl J Med 1992; 327:678-684Swedberg K., Held P., Kjekhus J. et al. for the CONSENSUS II study group. Effects of an early administration of enalapril on mortality in patients with myocardial infarction. Results of the Cooperative New Scandinavian Enalapril Survival Study II. New Engl J Med 1992; 327:678-684Vantrimpont P., Rouleau, Chuan-Chuan W, et al, for the SAVE investigators. Additive beneficial effects of beta-blockers to angiotensin-converting enzyme inhibitors in the Survival and Ventricular Enlargement (SAVE) Study. J Am Coll Cardiol. 1997; 29:229-326Vantrimpont P., Rouleau, Chuan-Chuan W, et al, for the SAVE investigators. Additive beneficial effects of beta-blockers to angiotensin-converting enzyme inhibitors in the Survival and Ventricular Enlargement (SAVE) Study. J Am Coll Cardiol. 1997; 29:229-326

The authors declare that there are no conflicts of interest present.