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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">evrazkar</journal-id><journal-title-group><journal-title xml:lang="ru">Евразийский Кардиологический Журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Eurasian heart journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2225-1685</issn><issn pub-type="epub">2305-0748</issn><publisher><publisher-name>Евразийская ассоциация кардиологов</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.38109/2225-1685-2020-1-140-145</article-id><article-id custom-type="elpub" pub-id-type="custom">evrazkar-5393</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЙ СЛУЧАЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASE</subject></subj-group></article-categories><title-group><article-title>КЛИНИЧЕСКИЙ СЛУЧАЙ РАЗВИТИЯ ОСТРОГО ИНФАРКТА МИОКАРДА ПРИ МИКРОСОСУДИСТОЙ СТЕНОКАРДИИ</article-title><trans-title-group xml:lang="en"><trans-title>CLINICAL CASE OF ACUTE MYOCARDIAL INFARCTION IN PATIENTS WITH MICROVASCULAR ANGINA</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2987-5148</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Минюк</surname><given-names>Ю. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Minyuk</surname><given-names>Yu. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минюк Юлия Игоревна, студент, помощник научного сотрудника, кафедра госпитальной терапии №2</p><p>г. Уфа</p></bio><bio xml:lang="en"><p>Minyuk Yulia Igorevna, Student, Assistant Researcher, Department of Hospital Therapy No. 2</p><p>Ufa</p></bio><email xlink:type="simple">yulia.minyuk@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0695-1774</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Салиева</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Saliyeva</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Салиева Екатерина Васильевна, студент, помощник научного сотрудника, кафедра госпитальной терапии №2</p><p>г. Уфа</p></bio><bio xml:lang="en"><p>Saliyeva Ekaterina Vasilievna, Student, Assistant Researcher, Department of Hospital Therapy No. 2</p><p>Ufa</p></bio><email xlink:type="simple">ektrn.slv@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2516-8032</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тамоян</surname><given-names>З. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Tamoyan</surname><given-names>Z. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тамоян Заира Самвеловна, студент, помощник научного сотрудника, кафедра госпитальной терапии №2</p><p>г. Уфа</p></bio><bio xml:lang="en"><p>Tamoyan Zaira Samvelovna, Student, Assistant Researcher, Department of Hospital Therapy No. 2</p><p>Ufa</p></bio><email xlink:type="simple">amirhan-14@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2044-9900</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Урманова</surname><given-names>Ю. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Urmanova</surname><given-names>Ju. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Урманова Юлия Рамилевна, студент, помощник научного сотрудника, кафедра госпитальной терапии №2</p><p>г. Уфа</p></bio><bio xml:lang="en"><p>Urmanova Julia Ramilevna, Student, Assistant Researcher, Department of Hospital Therapy No. 2</p><p>Ufa</p></bio><email xlink:type="simple">j-urmanova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1989-9058</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Таипова</surname><given-names>Л. У.</given-names></name><name name-style="western" xml:lang="en"><surname>Taipova</surname><given-names>L. U.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Таипова Ляйсан Уразбаевна, студент, помощник научного сотрудника, кафедра госпитальной терапии №2</p><p>г. Уфа</p></bio><bio xml:lang="en"><p>Taipova Laysan Urazbaevna, Student, Assistant Researcher, Department of Hospital Therapy No. 2</p><p>Ufa</p></bio><email xlink:type="simple">taipova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7723-8488</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хасанов</surname><given-names>А. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Khasanov</surname><given-names>A. Kh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хасанов Азат Хамитович, к. мед. наук, доцент, кафедра госпитальной терапии №2</p><p>450092, ул. Батырская, 39/2, г. Уфа</p><p>+73472724173</p></bio><bio xml:lang="en"><p>Khasanov Azat Khamitovich, PhD in Medicine, Associate Professor, Department of Hospital Therapy No. 2</p><p>450092, 39/2 Batyrskaya Str., Ufa</p></bio><email xlink:type="simple">azat.hasanov.71@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Башкирский государственный медицинский университет Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Bashkir State Medical University of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>30</day><month>03</month><year>2020</year></pub-date><volume>0</volume><issue>1</issue><fpage>140</fpage><lpage>145</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Минюк Ю.И., Салиева Е.В., Тамоян З.С., Урманова Ю.Р., Таипова Л.У., Хасанов А.Х., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Минюк Ю.И., Салиева Е.В., Тамоян З.С., Урманова Ю.Р., Таипова Л.У., Хасанов А.Х.</copyright-holder><copyright-holder xml:lang="en">Minyuk Y.I., Saliyeva E.V., Tamoyan Z.S., Urmanova J.R., Taipova L.U., Khasanov A.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.heartj.asia/jour/article/view/5393">https://www.heartj.asia/jour/article/view/5393</self-uri><abstract><sec><title>Цель работы</title><p>Цель работы. Описать клинический случай коронарной отягощенности без стенозирующего поражения магистральных ветвей венечных артерий у больного микрососудистой стенокардией с последующим развитием инфаркта миокарда с формированием ишемического гипокинеза передневерхушечной области левого желудочка при отсутствии повышенных уровней сывороточных маркеров некроза миокарда.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. За основу исследования взят единичный клинический случай. Объектом исследования является пациент, у которого были жалобы на давящие боли с локализацией за грудиной и иррадиацией в левую руку, сопровождающиеся смешанной одышкой, возникшие в покое, слабо купирующиеся короткодействующими нитратами и наркотическими анальгетиками, общей резкой слабостью. При первичном осмотре состояние больного средней степени тяжести, сознание ясное, положение активное, кожные покровы и видимые слизистые чистые, обычной окраски. Больному была проведена оценка лабораторных показателей, ЭКГ, эхо-кардиография (ЭХО-КГ), рентгенография органов грудной клетки (ОГК), коронароангиография (КАГ) с последующим переводом в отделение неотложной кардиологии.</p></sec><sec><title>Результаты</title><p>Результаты. Проведенное клинико-лабораторноное исследование выявило у больного наличие лейкоцитоза с клиникой острого коронарного синдрома, без повышения кардиоспецифических ферментов (КФК, КФК-МВ, тропониновый тест), а также высокую активность показателей коагулограммы (фибриноген, АЧТВ, РФМК). При проведении рентгенографии ОГК в прямой проекции – застойные легкие, картина хронического бронхита в сочетании с гипертрофией миокарда левого желудочка.</p></sec><sec><title>Заключение</title><p>Заключение. В представленном клиническом случае был описан пример развития ИМ при микрососудистом поражения коронарных артерий у больного манифестацией острого коронарного синдрома с выраженными длительными загрудинными болями и изменениями реполяризации на ЭКГ, а также без повышенных уровней сывороточных маркеров некроза миокарда, что, вероятно, обусловливает определение этого состояния как нестабильной (или острой) микрососудистой дисфункции с развитием инфаркта миокарда.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Purpose</title><p>Purpose. To describe a clinical case of coronary burden without stenosing lesions of the main branches of the coronary arteries in a patient with microvascular angina with subsequent development of myocardial infarction with the formation of ischemic hypokinesis of the anterior-apical region of the left ventricle in the absence of elevated levels of serum markers of myocardial necrosis.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study is based on a single clinical case. The object of the study is the patient in whom there were complaints of pressing pain localized behind the sternum and radiating to the left arm, accompanied by a mixed shortness of breath that occurred at rest, poorly stoped short-range nitrates and narcotic analgesics, sharp General weakness. Under primary inspection state of ailing average extent of gravity, consciousness clear, position active, skin integuments and visible mucous of clean, conventional painting. The patient was evaluated laboratory parameters, ECG, echo-cardiography (ECHO-kg), chest x-ray (OGK), coronary angiography (CAG), followed by transfer to the emergency Department of cardiology.</p></sec><sec><title>Results</title><p>Results. The conducted clinical and laboratory study revealed the presence of leukocytosis in the patient with the clinic of acute coronary syndrome, without increasing cardiospecific enzymes (CFC, CFC-MB, troponin test), as well as high activity of coagulogram indicators (fibrinogen, ACTV, rfmc). When conducting radiography of OGK in direct projection-congestive lungs, a picture of chronic bronchitis in combination with left ventricular myocardial hypertrophy.</p></sec><sec><title>Conclusion</title><p>Conclusion. In the presented clinical case was described an example of development of microvascular lesions in coronary arteries in a patient with manifestation of acute coronary syndrome with severe prolonged chest pain and repolarization changes on ECG and without elevated levels of serum markers of myocardial necrosis, which probably leads to the definition of this state as fragile (or sharp) microvascular dysfunction with myocardial infarction.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>микрососудистая стенокардия</kwd><kwd>микрососудистая дисфункция</kwd><kwd>коронарный синдром</kwd><kwd>коронарная артерия</kwd><kwd>коагуляционная нестабильность системы гемостаза</kwd></kwd-group><kwd-group xml:lang="en"><kwd>microvascular angina</kwd><kwd>microvascular dysfunction</kwd><kwd>coronary syndrome</kwd><kwd>coronary artery</kwd><kwd>coagulation instability of the hemostasis system</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Карпов Ю.А., Соболева Г.Н., Ерпылова Е.А. 2018. 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