Tobacco use and exposure to tobacco smoke have serious negative consequences for health, the economy, the environment and the social sphere. People should be informed about these negative effects and the benefits of stopping tobacco use. Awareness of such negative consequences for the majority of tobacco users serves as a rather strong motivating factor in favor of refusing to use it. Promoting tobacco cessation and tobacco dependence treatment is an important element of a comprehensive, integrated tobacco control program. Health workers play a central role in identifying tobacco users, raising their awareness, promoting tobacco cessation, and providing support to tobacco users who want to quit tobacco addiction. There is clear scientific evidence that tobacco dependence treatment is effective, and it is a cost-effective medical intervention. Aim of the study was the analysis of the results of the WHO PEN clinical protocol implementation of healthy lifestyle education and advice on stopping tobacco use in patients with cardiovascular pathology in primary health care.