evrazkarЕвразийский Кардиологический ЖурналEurasian heart journal2225-16852305-0748Евразийская ассоциация кардиологов10.38109/2225-1685-2019-3-4-33evrazkar-334Research ArticleКЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИCLINICAL GUIDELINESДИАГНОСТИКА И ЛЕЧЕНИЕ МИОКАРДИТОВDIAGNOSIS AND TREATMENT OF MYOCARDITIDESТерещенкоС. Н.TereshchenkoS. N.

проф.

Москва

Professor

Moscow

noemail@neicon.ruЖировИ. В.ZhirovI. V.

– д.м.н.

Москва

MD

Moscow

noemail@neicon.ruМасенкоВ. П.MasenkoV. P.

проф

Москва

Professor, MD

Moscow

noemail@neicon.ruНарусовО. Ю.NarusovO. Yu.

к.м.н.

Москва

Ph.D.

Moscow

noemail@neicon.ruНасоноваС. Н.NasonovaS. N.

к.м.н.

Москва

Ph.D.

Moscow

noemail@neicon.ruСамкоА. Н.SamkoA. N.

проф

Москва

 

MD

Moscow

noemail@neicon.ruСтукаловаО. В.StukalovaO. V.

к.м.н.

Москва

Ph.D

Moscow

noemail@neicon.ruШарияМ. А.ShariyaM. A.

д.м.н.

Москва

MD

Moscow

noemail@neicon.ru20193009201903433Copyright © Терещенко С.Н., Жиров И.В., Масенко В.П., Нарусов О.Ю., Насонова С.Н., Самко А.Н., Стукалова О.В., Шария М.А., 20192019Терещенко С.Н., Жиров И.В., Масенко В.П., Нарусов О.Ю., Насонова С.Н., Самко А.Н., Стукалова О.В., Шария М.А.Tereshchenko S.N., Zhirov I.V., Masenko V.P., Narusov O.Y., Nasonova S.N., Samko A.N., Stukalova O.V., Shariya M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.heartj.asia/jour/article/view/334

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ReferencesГиляревский С.Р. Миокардиты: современные подходы к диагностике и лечению. М.: Медиа-Сфера, 2008. – 324 с.Gilyarevsky S.R. Myocarditides: modern approaches to diagnosis and treatment. M.: Media-Sfera, 2008. – 324 p. (in Russian)Жиров И.В., Терещенко С.Н. Миокардиты. В кн.: Руководство по кардиологии. Под редакцией Чазова Е.И. - М.: «Практика», 2014 - Т.4. – С.309-344Zhirov I.V., Tereshchenko S.N. Myocarditides. In: Manual on cardiology. Ed. By Chazov E.I – M.: Praktika, 2014 – V.4. – P.309-344 (in Russian)Масенко В.П., Терещенко С.Н., Скворцов А.А., Нарусов О.Ю., Зыков К.А., Белявский Е.А., Щедрина А.Ю. Воспалительная кардиомиопатия: современное состояние проблемы. Терапевтический архив, 2010.-N 8.-С.62-71.Masenko V.P., Tereshchenko S.N., Skvortsov A.A., Narusov OYu., Zykov K.A., Belyavsky E.A., Shcherina A.Yu. Inflammatory cardiomyopathy: modern state of problem. Therapeutic Archives, 2010.-No. 8.- P.62-71. (in Russian)Моисеев В.С., Киякбаев Г.К. Кардиомиопатии и миокардиты. М.: Гэотар-Медиа, 2012. – 350 сMoiseyev V.S., Kiyakbaev G.K. Cardioyopathies and myocarditides. M.:Geotar-Media, 2012. – 350 p.Палеев Н.Р. Миокардиты. В кн.: Руководство по внутренним болезням. Болезни органов кровообращения. Под ред. Е.И. Чазова. М.: Медицина, 1997; 543—61.Paleyev N.R. Myocarditides. In: Manual on internal diseases. Diseases of the circulatory system organs. Ed. By E.I. Chazov. M.:Medicina, 1997; 543—61. (in Russian)Сторожаков Г.И., Гендлин Г. Е., Тронина О. А. Миокардиты. Сердечная недостаточность 2009; 10 (1): 46-52.Storozhakov G.I., Gendlin G.E., Tronina O.A. Myocarditides. Cardiac Insufficiency 2009; 10 (1): 46-52. (in Russian)Терещенко С.Н., Жиров И.В., Нарусов О.Ю., Мареев Ю.В., Затейщиков Д.А., Осмоловская Ю.Ф., Овчинников А.Г., Самко А.Н., Насонова С.Н., Стукалова О.В., Саидова М.А., Скворцов А.А., Шария М.А., Явелов И.С. Диагностика и лечение хронической и острой сердечной недостаточности. Кардиологический вестник, 2016.-N 2.-С.3-33Treshchenko S.N., Zhirov I.V., Narusov O.Yu., Mareyev Yu.V., Zateishchikov D.A., Osmolovskaya Yu.F., Ovchinnikov A.G., Samko A.N., Nasonova S.N., Stukalova O.V., Saidova M.A., Skvortsov A.A., Shariya M.A., Yavelov I.S. Diagnosis and treatment of chronic and acute cardiac insufficiency. Cardiological Herald, 2016.-No. 2.-P.3-33 (in Russian)Терещенко С.Н., Скворцов А.А., Щедрина А.Ю., Нарусов О.Ю., Зыков К.А., Сафиуллина А.А., Сычев А.В., Жиров И.В. Диагностическая значимость иммунологических маркеров у больных воспалительной кардиомиопатией. Российский кардиологический журнал. – 2017. – №2. – С. 22-29. DOI: http://dx.doi.org/10.15829/1560-4071-2017-2-22-29Tereshchenko S.N., Skvortsov A.A., Shchdrina A.Yu., Narusov O.Yu., Zykov K.A., Safiullina A.A., Sychev A.V., Zhirov I.V. Diagnostic significance of immunologic markers in the patients with inflammatory cardiomyopathy. Russian Cardiologic Journal. – 2017. – No.2. – P. 22-29. DOI: http://dx.doi.org/10.15829/1560-4071-2017-2-22-29 (in Russian)Ющук Н.Д., Терещенко С.Н., Сафиуллина Н.Х., Жиров И.В., Васюк Ю.А. HCV-инфекция и заболевания сердечно-сосудистой системы. Терапевтический архив. – 2007. - №9. – С.84-87.Yuchshuk N.D., Tereshchenko S.N., Safiullina N.H., Zhirov I.V., Vasyuk Yu.A., HCV-infection and diseases of the cardiovascular system. Therapeutic Archives. – 2007. – No. 9. – P.84-87.Abdel-Aty H, Simonetti O, Friedrich MG. T2-weighted cardiovascular magnetic resonance imaging. J Magn Reson Imaging 2007; 26:452–459.Abdel-Aty H, Simonetti O, Friedrich MG. T2-weighted cardiovascular magnetic resonance imaging. J Magn Reson Imaging 2007; 26:452–459.Ali, M.A. and Abdel-Dayem, T.M.K. (2003) Myocarditis: an expected health hazard associated with water resources contaminated with Coxsackie viruses type B. International Journal of Environmental Health Research, 13(3), 261–270.Ali, M.A. and Abdel-Dayem, T.M.K. (2003) Myocarditis: an expected health hazard associated with water resources contaminated with Coxsackie viruses type B. International Journal of Environmental Health Research, 13(3), 261–270.Aretz HT, Billingham ME, Edwards WD et al: Myocarditis: A histopathologic definition and classification. Am J Cardiovasc Pathol 1987;1:3.Aretz HT, Billingham ME, Edwards WD et al: Myocarditis: A histopathologic definition and classification. Am J Cardiovasc Pathol 1987;1:3.Baandrup U, Florio RA, Olsen EG. Do endomyocardial biopsies represent the morphology of the rest of the myocardium? A quantitative light microscopic study of single v. multiple biopsies with the King’s bioptome. Eur Heart J 1982;3:171–8.Baandrup U, Florio RA, Olsen EG. Do endomyocardial biopsies represent the morphology of the rest of the myocardium? A quantitative light microscopic study of single v. multiple biopsies with the King’s bioptome. Eur Heart J 1982;3:171–8.Baboonian C, Treasure T. Meta-analysis of the association of enteroviruses with human heart disease. Heart. 1997;78:539 –543.Baboonian C, Treasure T. Meta-analysis of the association of enteroviruses with human heart disease. Heart. 1997;78:539–543.Basso C., Calabrese F., Corrado D., Thiene G. Postmortem diagnosis in sudden cardiac death victims: macroscopic, microscopic and molecular findings. Cardiоvasc. Res., 2001;50: 290–300.Basso C., Calabrese F., Corrado D., Thiene G. Postmortem diagnosis in sudden cardiac death victims: macroscopic, microscopic and molecular findings. Cardiоvasc. Res., 2001;50: 290–300.Baughman KL. Diagnosis of myocarditis: death of Dallas criteria. Circulation 2006;113:593-5.Baughman KL. Diagnosis of myocarditis: death of Dallas criteria. Circulation 2006;113:593-5.Billingham ME. Acute myocarditis: is sampling error a contraindicationBillingham ME. Acute myocarditis: is sampling error a contraindication.Bock CT, Klingel K, Kandolf R. Human parvovirus B19-associated myocarditis. N Engl J Med. 2010;362:1248-9.Bock CT, Klingel K, Kandolf R. Human parvovirus B19-associated myocarditis. N Engl J Med. 2010;362:1248-9.Bowles NE, Ni J, Kearney DL, et al: Detection of viruses in myocardial tissues by polymerase chain reaction: Evidence of adenovirus as a common cause of myocarditis in children and adults. J Am Coll Cardiol 2003 42:466-72.Bowles NE, Ni J, Kearney DL, et al: Detection of viruses in myocardial tissues by polymerase chain reaction: Evidence of adenovirus as a common cause of myocarditis in children and adults. J Am Coll Cardiol 2003 42:466-72.Breinholt JP, Moulik M, Dreyer WJ, et al. Viral epidemiologic shift in inflammatory heart disease: the increasing involvement of parvovirus B19 in the myocardium of pediatric cardiac transplant patients. J Heart Lung Transplant 2010;29:739–46.Breinholt JP, Moulik M, Dreyer WJ, et al. Viral epidemiologic shift in inflammatory heart disease: the increasing involvement of parvovirus B19 in the myocardium of pediatric cardiac transplant patients. J Heart Lung Transplant 2010;29:739–46.Caforio AL, Pankuweit S, Arbustini E, Basso C, Gimeno-Blanes J, Felix SB, Fu M, Helio T, Heymans S, Jahns R, Klingel K, Linhart A, Maisch B, McKenna W, Mogensen J, Pinto YM, Ristic A, Schultheiss HP, Seggewiss H, Tavazzi L, Thiene G, Yilmaz A, Charron P, Elliott PM; European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J 2013;34:2636–2648, 2648a–2648d.Caforio AL, Pankuweit S, Arbustini E, Basso C, Gimeno-Blanes J, Felix SB, Fu M, Helio T, Heymans S, Jahns R, Klingel K, Linhart A, Maisch B, McKenna W, Mogensen J, Pinto YM, Ristic A, Schultheiss HP, Seggewiss H, Tavazzi L, Thiene G, Yilmaz A, Charron P, Elliott PM; European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J 2013;34:2636–2648, 2648a–2648d.Caves PK, Stinson EB, Graham AF, Billingham ME, Grehl TM, Shumway NE. Percutaneous transvenous endomyocardial biopsy. JAMA 1973;225:288 –91.Caves PK, Stinson EB, Graham AF, Billingham ME, Grehl TM, Shumway NE. Percutaneous transvenous endomyocardial biopsy. JAMA 1973;225:288 –91.Chen C, Li R, Ross RS, Manso AM. Integrins and integrin-related proteins in cardiac fibrosis. J Mol Cell Cardiol 2016;93:162–174.Chen C, Li R, Ross RS, Manso AM. Integrins and integrin-related proteins in cardiac fibrosis. J Mol Cell Cardiol 2016;93:162–174.Chow LH, Radio SJ, Sears TD, McManus BM. Insensitivity of right ventricular endomyocardial biopsy in the diagnosis of myocarditis. J Am Coll Cardiol 1989; 14: 915–920.Chow LH, Radio SJ, Sears TD, McManus BM. Insensitivity of right ventricular endomyocardial biopsy in the diagnosis of myocarditis. J Am Coll Cardiol 1989; 14: 915–920.Cooper LT Jr. Myocarditis. N Engl J Med 2009;360:1526–38.Cooper LT Jr. Myocarditis. N Engl J Med 2009;360:1526–38.Cooper LT, Baughman KL, Feldman AM et al. The Role of Endomyocardial Biopsy in the Management of Cardiovascular Disease: A Scientific Statement From the American Heart Association, the American College of Cardiology, and the European Society of Cardiology. J of the American College of Cardiology 2007; 50 (19): 1914–1931.Cooper LT, Baughman KL, Feldman AM et al. The Role of Endomyocardial Biopsy in the Management of Cardiovascular Disease: A Scientific Statement From the American Heart Association, the American College of Cardiology, and the European Society of Cardiology. J of the American College of Cardiology 2007; 50 (19): 1914–1931.den Uil CA, Akin S, Jewbali LS, Dos Reis Miranda D, Brugts JJ, Constantinescu AA, Kappetein AP, Caliskan K. Shortterm mechanical circulatory support as a bridge to durable left ventricular assist device implantation in refractory cardiogenic shock: a systematic review and meta-analysis. Eur J Cardiothorac Surg 2017;52:14–25.den Uil CA, Akin S, Jewbali LS, Dos Reis Miranda D, Brugts JJ, Constantinescu AA, Kappetein AP, Caliskan K. Shortterm mechanical circulatory support as a bridge to durable left ventricular assist device implantation in refractory cardiogenic shock: a systematic review and meta-analysis. Eur J Cardiothorac Surg 2017;52:14–25.Dennert R., Crijns H.L., Heymans S. Acute viral myocarditis. Eur. Heart J., 2008;29: 2073–2082.Dennert R., Crijns H.L., Heymans S. Acute viral myocarditis. Eur. Heart J., 2008;29: 2073–2082.Donoso-Mantke O, Meyer R, Prösch S, et al. High prevalence of cardiotropic viruses in myocardial tissue from explanted hearts of heart transplant recipients and heart donors: a 3-year retrospective study from a German patients’ pool. J Heart Lung Transplant 2005;24:1632-1638/Donoso-Mantke O, Meyer R, Prösch S, et al. High prevalence of cardiotropic viruses in myocardial tissue from explanted hearts of heart transplant recipients and heart donors: a 3-year retrospective study from a German patients’ pool. J Heart Lung Transplant 2005;24:1632-1638/Doolan A., Langlois N., Semsarian C. Causes of sudden cardiac death in young Australians. Med. J. Aust., 2004;180: 110–112.Doolan A., Langlois N., Semsarian C. Causes of sudden cardiac death in young Australians. Med. J. Aust., 2004;180: 110–112.Dunn J J, Chapman N M, Tracy S et al. Genomic determinants of cardiovirulence in coxsackievirus B3 clinical isolates: localization to the 5’ nontranslated region. J Virol 2000; 74: 4787–94.Dunn J J, Chapman N M, Tracy S et al. Genomic determinants of cardiovirulence in coxsackievirus B3 clinical isolates: localization to the 5’ nontranslated region. J Virol 2000; 74: 4787–94.for diagnostic biopsies? J Am Coll Cardiol 1989;14:921–2.for diagnostic biopsies? J Am Coll Cardiol 1989;14:921–2.Freimuth P, Philipson L, Carson SD. The coxsackievirus and adenovirus receptor. Curr Top Microbiol Immunol 2008;323:67–87.Freimuth P, Philipson L, Carson SD. The coxsackievirus and adenovirus receptor. Curr Top Microbiol Immunol 2008;323:67–87.Friedrich MG, Sechtem U, Schulz-Menger J et al. Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper. 2009; 53 (17): 1475–1487.Friedrich MG, Sechtem U, Schulz-Menger J et al. Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper. 2009; 53 (17): 1475–1487.Griffiths P D, Hannington G, Booth J C. Coxsackie B virus infections and myocardial infarction. Results from a prospective, epidemiologically controlled study. Lancet 1980; 1: 1387–9.Griffiths P D, Hannington G, Booth J C. Coxsackie B virus infections and myocardial infarction. Results from a prospective, epidemiologically controlled study. Lancet 1980; 1: 1387–9.Heymans S, Eriksson U, Lehtonen J, Cooper LT Jr. The quest for new approaches in myocarditis and inflammatory cardiomyopathy. J Am Coll Cardiol2016;68:2348–2364.Heymans S, Eriksson U, Lehtonen J, Cooper LT Jr. The quest for new approaches in myocarditis and inflammatory cardiomyopathy. J Am Coll Cardiol2016;68:2348–2364.Hillingso, J. G., I. P. Jensen, and L. Tom-Petersen. Parvovirus B19 and acute hepatitis in adults. Lancet 1998;351:955-956.Hillingso, J. G., I. P. Jensen, and L. Tom-Petersen. Parvovirus B19 and acute hepatitis in adults. Lancet 1998;351:955-956.Hrobon P, Kuntz M, Hare JM. Should endomyocardial biopsy be performed for detection of myocarditis? A decision analytic approach. J Heart Lung Transplant 1998; 17: 479-486.Hrobon P, Kuntz M, Hare JM. Should endomyocardial biopsy be performed for detection of myocarditis? A decision analytic approach. J Heart Lung Transplant 1998; 17: 479-486.Kaufmann, B. The structure of human parvovirus B19 / B. Kaufmann, A.A. Simpson, M.G. Rossmann // Proc. Natl. Acad. Sci. U. S. A. –2004. –V. 101. –P. 11628–11633.Kaufmann, B. The structure of human parvovirus B19 / B. Kaufmann, A.A. Simpson, M.G. Rossmann // Proc. Natl. Acad. Sci. U. S. A. –2004. –V. 101. –P. 11628–11633.Kawai C. From myocarditis to cardiomyopathy: mechanisms of inflammation and cell death: learning from the past for the future. Circulation 1999;99:1091–100.Kawai C. From myocarditis to cardiomyopathy: mechanisms of inflammation and cell death: learning from the past for the future. Circulation 1999;99:1091–100.Kawai C. From myocarditis to cardiomyоpathy: mechanisms of inflammation and cell death: learning from the past for the future. Circulation 1999; 99: 1091-1100.Kawai C. From myocarditis to cardiomyоpathy: mechanisms of inflammation and cell death: learning from the past for the future. Circulation 1999; 99: 1091-1100.Kindermann I, Kindermann M, Kandolf R, et al. Predictors of outcome in patients with suspected myocarditis. Circulation 2008;118:639-48.Kindermann I, Kindermann M, Kandolf R, et al. Predictors of outcome in patients with suspected myocarditis. Circulation 2008;118:639-48.Kindermann I., Barth Ch., Mahfoud F. et al. Update on Myocarditis. JACC 2012;9:779-792.Kindermann I., Barth Ch., Mahfoud F. et al. Update on Myocarditis. JACC 2012;9:779-792.Kishimoto C, Hiraoka Y. Clinical and experimental studies in myocarditis. Curr Opin Cardiol 1994; 9: 349–356.Kishimoto C, Hiraoka Y. Clinical and experimental studies in myocarditis. Curr Opin Cardiol 1994; 9: 349–356.Kuethe F, Lindner J, Matschke K, Wenzel JJ, Norja P, Ploetze K, Schaal S, Kamvissi V, Bornstein SR, Schwanebeck U, Modrow S. Prevalence of parvovirus B19 and human bocavirus DNA in the heart of patients with no evidence of dilated cardiomyopathy or myocarditis. Clin Infect Dis. 2009;49(11):1660-6.Kuethe F, Lindner J, Matschke K, Wenzel JJ, Norja P, Ploetze K, Schaal S, Kamvissi V, Bornstein SR, Schwanebeck U, Modrow S. Prevalence of parvovirus B19 and human bocavirus DNA in the heart of patients with no evidence of dilated cardiomyopathy or myocarditis. Clin Infect Dis. 2009;49(11):1660-6.Kühl U, Pauschinger M, Noutsias M, et al. High prevalence of viral genomes and multiple viral infections in the myocardium of adults with «idiopathic» left ventricular dysfunction. Circulation 2005;111(7):887–93.Kühl U, Pauschinger M, Noutsias M, et al. High prevalence of viral genomes and multiple viral infections in the myocardium of adults with «idiopathic» left ventricular dysfunction. Circulation 2005;111(7):887–93.Lauer B, Niederau C, Kuhl U, et al. Cardiac troponin T in patients with clinically suspected myocarditis. J Am Coll Cardiol 1997;30:1354–9.Lauer B, Niederau C, Kuhl U, et al. Cardiac troponin T in patients with clinically suspected myocarditis. J Am Coll Cardiol 1997;30:1354–9.Levin HR, Oz MC, Chen JM, Packer M, Rose EA, Burkhoff D. Reversal of chronic ventricular dilation in patients with endstage cardiomyopaty by prolonged mechanical unloading. Circulation 1995;91:2717–2720.Levin HR, Oz MC, Chen JM, Packer M, Rose EA, Burkhoff D. Reversal of chronic ventricular dilation in patients with endstage cardiomyopathy by prolonged mechanical unloading. Circulation 1995;91:2717–2720.Lie JT. Myocarditis and endomyocardial biopsy in unexplained heart failure: a diagnosis in search of a disease. Ann Intern Med 1988; 109:5258.Lie JT. Myocarditis and endomyocardial biopsy in unexplained heart failure: a diagnosis in search of a disease. Ann Intern Med 1988; 109:5258.Lima J.A., Judd R., Bazille A. et al. Regional heterogenity of human myocardial infarcts demonstrated by contrast-enhanced MRI: potential mechanisms. Circulation. 1995;92:1117-1125.Lima J.A., Judd R., Bazille A. et al. Regional heterogenity of human myocardial infarcts demonstrated by contrast-enhanced MRI: potential mechanisms. Circulation. 1995;92:1117-1125.Lindner D, Zietsch C, Tank J, Sossalla S, Fluschnik N, Hinrichs S, Maier L, Poller W, Blankenberg S, Schultheiss HP, Tschope C, Westermann D. Cardiac fibroblasts support cardiac inflammation in heart failure. Basic Res Cardiol 2014;109:428.Lindner D, Zietsch C, Tank J, Sossalla S, Fluschnik N, Hinrichs S, Maier L, Poller W, Blankenberg S, Schultheiss HP, Tschope C, Westermann D. Cardiac fibroblasts support cardiac inflammation in heart failure. Basic Res Cardiol 2014;109:428.Liu PP, Mason JW. Advances in the understanding of myocarditis. Circulation 2001;104:1076–82.Liu PP, Mason JW. Advances in the understanding of myocarditis. Circulation 2001;104:1076–82.Mahfoud F, Gartner B, Kindermann M, et al. Virus serology in patients with suspected myocarditis: utility or futility? Eur Heart J 2011;32:897–903.Mahfoud F, Gartner B, Kindermann M, et al. Virus serology in patients with suspected myocarditis: utility or futility? Eur Heart J 2011;32:897–903.Mahrholdt H, Wagner A, Deluigi CC et al. Presentation, patterns of myocardial damage, and clinical course of viral myocarditis. Circulation 2006; 114: 1581-90.Mahrholdt H, Wagner A, Deluigi CC et al. Presentation, patterns of myocardial damage, and clinical course of viral myocarditis. Circulation 2006; 114: 1581-90.Mason J.W. Myocarditis and dilated cardiomyopathy: an inflammatory link. Cardiovasc. Res., 2003; 60: 5–10.Mason J.W. Myocarditis and dilated cardiomyopathy: an inflammatory link. Cardiovasc. Res., 2003; 60: 5–10.Mason JW, O’Connell JB, Herskowitz A et al. A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators. N Engl J Med 1995; 333(5):269-275.Mason JW, O’Connell JB, Herskowitz A et al. A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators. N Engl J Med 1995; 333(5):269-275.Matsumori A, Shimada T, Chapman NM, Tracy SM, Mason JW. Myocarditis and heart failure associated with hepatitis C virus infection. J Card Fail 2006;12:293-8.Matsumori A, Shimada T, Chapman NM, Tracy SM, Mason JW. Myocarditis and heart failure associated with hepatitis C virus infection. J Card Fail 2006;12:293-8.Miller LW, Labovitz AJ, McBride LA, Pennington DG, Kanter K. Echocardiography-guided endomyocardial biopsy: a 5-year experience. Circulation 1988;78:99 –102.Miller LW, Labovitz AJ, McBride LA, Pennington DG, Kanter K. Echocardiography-guided endomyocardial biopsy: a 5-year experience. Circulation 1988;78:99 –102.Morgera T, Di Lenarda A, Dreas L, et al. Electrocardiography of myocarditis revisited: clinical and prognostic significance of electrocardiographic changes. Am Heart J 1992;124:455–67.Morgera T, Di Lenarda A, Dreas L, et al. Electrocardiography of myocarditis revisited: clinical and prognostic significance of electrocardiographic changes. Am Heart J 1992;124:455–67.Muir P, Nicholson F, Jhetam M, Neogi S, Banatvala JE. Rapid diagnosis of enterovirus infection by magnetic bead extraction and polymerase chain reaction detection of enterovirus RNA in clinical specimens. J Clin Microbiol 1993;31: 31–8.Muir P, Nicholson F, Jhetam M, Neogi S, Banatvala JE. Rapid diagnosis of enterovirus infection by magnetic bead extraction and polymerase chain reaction detection of enterovirus RNA in clinical specimens. J Clin Microbiol 1993;31: 31–8.Muller I, Vogl T, Pappritz K, Miteva K, Savvatis K, Rohde D, Most P, Lassner D, Pieske B, Kuhl U, Van Linthout S, Tschope C. Pathogenic role of the damage associated molecular patterns S100A8 and S100A9 in coxsackievirus B3-induced myocarditis. Circ Heart Fail 2017;10:e004125.Muller I, Vogl T, Pappritz K, Miteva K, Savvatis K, Rohde D, Most P, Lassner D, Pieske B, Kuhl U, Van Linthout S, Tschope C. Pathogenic role of the damage associated molecular patterns S100A8 and S100A9 in coxsackievirus B3-induced myocarditis. Circ Heart Fail 2017;10:e004125.Nakashima H, Katayama T, Ishizaki M, Takeno M, Honda Y, Yano K. Q wave and non-Q wave myocarditis with special reference to clinical significance. Jpn Heart J 1998;39:763–74.Nakashima H, Katayama T, Ishizaki M, Takeno M, Honda Y, Yano K. Q wave and non-Q wave myocarditis with special reference to clinical significance. Jpn Heart J 1998;39:763–74.Noutsias M, Fechner H, de Jonge H, et al. Human coxsackieadenovirus receptor is colocalized with integrins alpha(v)beta(3) and alpha(v)beta(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: implications for cardiotropic viral infections. Circulation 2001;104:275–80.Noutsias M, Fechner H, de Jonge H, et al. Human coxsackieadenovirus receptor is colocalized with integrins alpha(v)beta(3) and alpha(v)beta(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: implications for cardiotropic viral infections. Circulation 2001;104:275–80.Perry P, David E, Atkins B, Raff G. Novel application of a percutaneous left ventricular assist device as a bridge to transplant in a paediatric patient with severe heart failure due to viral myocarditis. Interact Cardiovasc Thorac Surg 2017;24:474–476.Perry P, David E, Atkins B, Raff G. Novel application of a percutaneous left ventricular assist device as a bridge to transplant in a paediatric patient with severe heart failure due to viral myocarditis. Interact Cardiovasc Thorac Surg 2017;24:474–476.Ponikowski P, Voors AA, Anker SD et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 2016; 37: 2129–200. DOI:10.1093/eurheartj/ehw128Ponikowski P, Voors AA, Anker SD et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 2016; 37: 2129–200. DOI: 10.1093/eurheartj/ehw128Richardson P, McKenna W, Bristow M, et al. Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of Cardiomyopathies. Circulation 1996;93:841–2.Richardson P, McKenna W, Bristow M, et al. Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of Cardiomyopathies. Circulation 1996;93:841–2.Roditi GH, Hartnell GG, Cohen MC. MRI changes in myocarditis—evaluation with spin echo, cine MR angiography and contrast enhanced spin echo imaging. Clin Radiol 2000; 55: 752–758.Roditi GH, Hartnell GG, Cohen MC. MRI changes in myocarditis—evaluation with spin echo, cine MR angiography and contrast enhanced spin echo imaging. Clin Radiol 2000; 55: 752–758.Rohrer C, Gartner B, Sauerbrei A, et al. Seroprevalence of parvovirus B19 in the German population. Epidemiol Infect 2008; 136:1564–75.Rohrer C, Gartner B, Sauerbrei A, et al. Seroprevalence of parvovirus B19 in the German population. Epidemiol Infect 2008; 136:1564–75.Savvatis K, Schultheiss HP, Tschope C. Endomyocardial biopsy and ultrastructural changes in dilated cardiomyopathy: taking a ‘deeper’ look into patients’ prognosis. Eur Heart J 2015;36:708–710.Savvatis K, Schultheiss HP, Tschope C. Endomyocardial biopsy and ultrastructural changes in dilated cardiomyopathy: taking a ‘deeper’ look into patients’ prognosis. Eur Heart J 2015;36:708–710.Schenk T, Enders M, Pollak S, Hahn R, Huzly D. High prevalence of human parvovirus B19 DNA in myocardial autopsy samples from subjects without myocarditis or dilative cardiomyopathy. J Clin Microbiol. 2009;47:106 –110.Schenk T, Enders M, Pollak S, Hahn R, Huzly D. High prevalence of human parvovirus B19 DNA in myocardial autopsy samples from subjects without myocarditis or dilative cardiomyopathy. J Clin Microbiol. 2009;47:106–110.Schowengerdt KO, Ni J, Denfield SW, et al. Association of parvovirus B19 genome in children with myocarditis and cardiac allograft rejection: diagnosis using the polymerase chain reaction. Circulation. 1997;96:3549 –3554.Schowengerdt KO, Ni J, Denfield SW, et al. Association of parvovirus B19 genome in children with myocarditis and cardiac allograft rejection: diagnosis using the polymerase chain reaction. Circulation. 1997;96:3549–3554.Shanes JG, Ghali J, Billingham ME et al. Interobserver variability in the pathologic interpretation of endomyocardial biopsy results. Circulation 1987; 75: 401- 405.Shanes JG, Ghali J, Billingham ME et al. Interobserver variability in the pathologic interpretation of endomyocardial biopsy results. Circulation 1987; 75: 401- 405.Shi Y, Chen C, Lisewski U, et al. Cardiac deletion of the Coxsackievirus-adenovirus receptor abolishes Coxsackievirus B3 infection and prevents myocarditis in vivo. J Am Coll Cardiol 2009; 53:1219–26.Shi Y, Chen C, Lisewski U, et al. Cardiac deletion of the Coxsackievirus-adenovirus receptor abolishes Coxsackievirus B3 infection and prevents myocarditis in vivo. J Am Coll Cardiol 2009; 53:1219–26.Smith SC, Ladenson JH, Mason JW, Jaffe AS. Elevations of cardiac troponin I associated with myocarditis. Experimental and clinical correlates. Circulation 1997;95:163–8.Smith SC, Ladenson JH, Mason JW, Jaffe AS. Elevations of cardiac troponin I associated with myocarditis. Experimental and clinical correlates. Circulation 1997;95:163–8.Soderlund-Venermo M, Hokynar K, Nieminen J, Rautakorpi H, Hedman K. Persistence of human parvovirus B19 in human tissues. Pathol Biol (Paris) 2002; 50:307–16.Soderlund-Venermo M, Hokynar K, Nieminen J, Rautakorpi H, Hedman K. Persistence of human parvovirus B19 in human tissues. Pathol Biol (Paris) 2002; 50:307–16.Tschope C, Muller I, Xia Y, Savvatis K, Pappritz K, Pinkert S, Lassner D, Heimesaat MM, Spillmann F, Miteva K, Bereswill S, Schultheiss HP, Fechner H, Pieske B, Kuhl U, Van Linthout S. NOD2 (Nucleotide-Binding Oligomerization Domain 2) is a major pathogenic mediator of coxsackievirus B3-induced myocarditis. Circ Heart Fail 2017;10:e003870.Tschope C, Muller I, Xia Y, Savvatis K, Pappritz K, Pinkert S, Lassner D, Heimesaat MM, Spillmann F, Miteva K, Bereswill S, Schultheiss HP, Fechner H, Pieske B, Kuhl U, Van Linthout S. NOD2 (Nucleotide-Binding Oligomerization Domain 2) is a major pathogenic mediator of coxsackievirus B3-induced myocarditis. Circ Heart Fail 2017;10:e003870.Tschope C, Van Linthout S, Klein O, Mairinger T, Krackhardt F, Potapov E, Schmidt G, Burkhoff D, Pieske B, Spillmann F. Mechanical unloading by fulminant myocarditis: LV-IMPELLA, ECMELLA, BI-PELLA and PROPELLA concepts. J Cardiovasc Transl Res 2018. doi: 10.1007/s12265-018-9820-2.Tschope C, Van Linthout S, Klein O, Mairinger T, Krackhardt F, Potapov E, Schmidt G, Burkhoff D, Pieske B, Spillmann F. Mechanical unloading by fulminant myocarditis: LV-IMPELLA, ECMELLA, BI-PELLA and PROPELLA concepts. J Cardiovasc Transl Res 2018. doi: 10.1007/s12265-018-9820-2.Tschope C., Bock C.T., Kasner M. et al. High prevalence of cardiac parvovirus B19 infection in patients with isolated left ventricular diastolic dysfunction. Circulation 2005; 111: 7: 879—886.Tschope C., Bock C.T., Kasner M. et al. High prevalence of cardiac parvovirus B19 infection in patients with isolated left ventricular diastolic dysfunction. Circulation 2005; 111: 7: 879—886.Ukena C, Mahfoud F, Kindermann I, Kandolf R, Kindermann M, Bohm M. Prognostic electrocardiographic parameters in patients with suspected myocarditis. Eur J Heart Fail 2011;13:398–405.Ukena C, Mahfoud F, Kindermann I, Kandolf R, Kindermann M, Bohm M. Prognostic electrocardiographic parameters in patients with suspected myocarditis. Eur J Heart Fail 2011;13:398–405.Van Linthout S, Tschope C. Inflammation—cause or consequence of heart failure or both? Curr Heart Fail Rep 2017;14:251–265Van Linthout S, Tschope C. Inflammation—cause or consequence of heart failure or both? Curr Heart Fail Rep 2017;14:251–265Veinot JP. Diagnostic endomyocardial biopsy pathology— general biopsy considerations, and its use for myocarditis and cardiomyopathy: a review. Can J Cardiol 2002;18:55–65.Veinot JP. Diagnostic endomyocardial biopsy pathology—general biopsy considerations, and its use for myocarditis and cardiomyopathy: a review. Can J Cardiol 2002;18:55–65.Vogel-Claussen J., Rochitte C.E., Wu K.C., Kameri.R., Foo Т.К., Lima J.A., Bluemke D.A. Delayed enhancement MR imaging: utility in myocardial assessment//Radiographics. 2006;26:795-810.Vogel-Claussen J., Rochitte C.E., Wu K.C., Kameri.R., Foo Т.К., Lima J.A., Bluemke D.A. Delayed enhancement MR imaging: utility in myocardial assessment//Radiographics. 2006;26:795-810.Yilmaz A, Kindermann I, Kindermann M, et al. Comparative evaluation of left and right ventricular endomyocardial biopsy: differences in complication rate and diagnostic performance. Circulation 2010;122:900–9.Yilmaz A, Kindermann I, Kindermann M, et al. Comparative evaluation of left and right ventricular endomyocardial biopsy: differences in complication rate and diagnostic performance. Circulation 2010;122:900–9.Young NS, Brown KE. Parvovirus B19. N Engl J Med. 2004;350: 586–597.Young NS, Brown KE. Parvovirus B19. N Engl J Med. 2004;350: 586–597.

The authors declare that there are no conflicts of interest present.