<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">evrazkar</journal-id><journal-title-group><journal-title xml:lang="ru">Евразийский Кардиологический Журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Eurasian heart journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2225-1685</issn><issn pub-type="epub">2305-0748</issn><publisher><publisher-name>Евразийская ассоциация кардиологов</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.38109/2225-1685-2018-4-36-50</article-id><article-id custom-type="elpub" pub-id-type="custom">evrazkar-307</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL PAPERS</subject></subj-group></article-categories><title-group><article-title>НОЗОЛОГИЧЕСКАЯ СТРУКТУРА ОСТРЫХ КОРОНАРНЫХ СОБЫТИЙ ПРИ ПОСТУПЛЕНИИ И ПРИ ВЫПИСКЕ ИЗ СТАЦИОНАРА, КОМПЛАЕНТНОСТЬ ПАЦИЕНТОВ И БЛИЖАЙШИЙ ПРОГНОЗ (ДАННЫЕ РЕГИСТРА «РОКСИМ-УЗ»)</article-title><trans-title-group xml:lang="en"><trans-title>NOSOLOGICAL STRUCTURE OF ACUTE CORONARY EVENTS AT ADMISSION AND AT DISCHARGE, PATIENT COMPLIANCE AND NEAREST FORECAST (DATA OF THE RACSMI-UZ REGISTER)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нагаева</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Nagaeva</surname><given-names>G. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., старший научный сотрудник отдела профилактики сердечно-сосудистых заболеваний </p><p>100057, Республика Узбекистан, г.Ташкент, ул.Осиё, 4,</p><p>тел.: +99897 747 75 83</p></bio><bio xml:lang="en"><p>Ph.D., Senior Researcher of the Department of Prevention of Cardiovascular Diseases </p><p>100057, The Republic of Uzbekistan, Tashkent, Osiyo Street, 4,</p><p>phone: +99897 747 75 83</p></bio><email xlink:type="simple">nagaeva.gulnora@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Республиканский специализированный научно-практический медицинский центр кардиологии МЗ РУз</institution><country>Узбекистан</country></aff><aff xml:lang="en"><institution>Republican Specialized Scientific and Practical Medical Center of Cardiology of the Ministry of Health of the Republic of Uzbekistan</institution><country>Uzbekistan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2018</year></pub-date><volume>0</volume><issue>4</issue><fpage>36</fpage><lpage>50</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Нагаева Г.А., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Нагаева Г.А.</copyright-holder><copyright-holder xml:lang="en">Nagaeva G.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.heartj.asia/jour/article/view/307">https://www.heartj.asia/jour/article/view/307</self-uri><abstract><sec><title>Введение</title><p>Введение. В статье на основании данных регистра «РОКСИМ-Уз» приводится сравнительный анализ структуры и трансформации диагнозов при острых коронарных состояниях в динамике (при госпитализации и при выписке), а также оценивается приверженность больных к медикаментозной терапии в зависимости от пола, и описывается анализ её влияния на ближайший прогноз.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Материал исследования составили 449 больных с ОКС/ОИМ, госпитализированных в соответствующие ЛПУ экспериментального района г. Ташкента. В зависимости от пола были выделены 2 группы пациентов: 1гр. - 243 больных мужского пола и 2гр. - 206 больных женского пола.</p></sec><sec><title>Результаты</title><p>Результаты. В ходе регистра было установлено, что ОКС/ОИМ чаще регистрировались у мужчин, чем у женщин (54,1% против 45,9%, соответственно). Мужчины по возрасту оказались моложе женщин (p&lt;0,05); у женщин превалировало ожирение различной степени выраженности (48,0% - у женщин против 29,6% - у мужчин, (р&lt;0,05). У лиц мужской популяции при госпитализации ОИМ регистрировался у 43 (17,7%) пациентов, однако при выписке из стационара наблюдалось увеличение числа больных с данным диагнозом (61 человек или 25,1%). Из 243 мужчин 3,7% умерли, при этом наибольшее количество смертельных случаев пришлось на начальный диагноз нестабильная стенокардия. В женской популяции при госпитализации частота ОИМ, как с зуб цом Q, так и без зубца Q констатировалась в 2 раза реже, чем при выписке из стационара (8,7% случаев при госпитализации и 17,5% случаев при выписке), что свидетельствует о низкой настороженности медработников при диагностике ОИМ у женщин. Смертность от ОКС/ОИМ среди женщин составила 3,4%, при этом наибольшее количество смертей пришлось на начальный диагноз ОИМбQ. Комплаентность у женщин была несколько выше, чем у мужчин; мужчины оказались склонны к приёму большего количества лекарственных препаратов (ЛП), хотя в пропорциональном соотношении по принимаемым ЛП существенных различий между мужчинами и женщинами выявлено не было. Между уровнем комплаентности пациентов и временным интервалом: от момента госпитализации до смерти респондента выявлена прямая корреляционная зависимость (p&gt;0,05).</p></sec><sec><title>Заключение</title><p>Заключение. ОКС/ОИМ чаще регистрировался у мужчин, нежели у женщин, при этом возраст мужчин был моложе (р&lt;0,05). Настороженность медицинских работников первичного звена по ОКС/ОИМ оказалась низкой, особенно для женщин. Комплаентность у женщин оказалась выше, чем у мужчин. При этом, чем выше была приверженность пациентов к терапии, тем устойчивее оказался организм к кардиострессам.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Basing on the data of the “RACSMI-UZ” register, the article provides comparative analysis of the structure and transformation of diagnoses during acute coronary conditions in the dynamics (at admission and discharge), assesses patients' adherence to drug therapy depending on gender and also describes analysis of its effect on the short-term prognosis.</p></sec><sec><title>Material and methods</title><p>Material and methods. The study material included 449 patients with ACS/AMI hospitalized to relevant health care facilities of the experimental district of Tashkent. Two groups of patients were distinguished depending on the gender: group 1 included 243 male patients, and group 2 consisted of 206 female patients.</p></sec><sec><title>Results</title><p> Results. The registration showed that ACS/AMI was more often observed in men than in women (54.1% vs. 45.9%, respectively). Male patients proved to be younger than female ones (p &lt;0.05); obesity of different degree prevailed in women (48.0% in women vs. 29.6% in men, p &lt;0.05). In the male population, AMI at admission was registered in 43 (17.7%) patients but the number of patients with this diagnosis increased at discharge (61 subjects, or 25.1%). Out of 243 men, 3.7% died and the largest number of deaths occurred in patients with initial diagnosis of unstable angina. In the female population, the incidence of AMI both with and without Q at admission was recorded 2 times less frequent than that at discharge from the hospital (8.7% of cases at admission and 17.5% of cases at discharge), which shows low vigilance of healthcare professionals in diagnostics of AMI in women. Mortality from ACS/ AMI in women was 3.4% with the largest number of deaths being associated with the initial diagnosis of AMI without Q. Compliance in females was somewhat higher than in males; men were prone to taking more medications (Mc’s), though there were no significant differences between men and women by the proportion of Mc’s taken. The direct correlation was found between the patients’ compliance level and the time interval: from admission to death of the respondent (p&gt; 0.05).</p></sec><sec><title>Conclusion</title><p>Conclusion. ACS / AMI was more often recorded in men than in women, while the age of men was younger (p&lt;0.05). Alertness of primary care physicians in ACS / AMI was low, especially for women. Compliance in women was higher than in men. Thus, the higher was the patient adherence to therapy, the more stable the body appeared to cardio stress.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>регистр</kwd><kwd>острый инфаркт миокарда</kwd><kwd>острый коронарный синдром</kwd><kwd>мужчины</kwd><kwd>женщины</kwd><kwd>комплаентность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>register</kwd><kwd>acute myocardial infarction</kwd><kwd>acute coronary syndrome</kwd><kwd>men</kwd><kwd>women</kwd><kwd>compliance</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Alpert J.S. Are data from clinical registries of any value? Eur Hear. J. 2000; 21(17):1399-1401.</mixed-citation><mixed-citation xml:lang="en">Alpert J.S. Are data from clinical registries of any value? Eur Hear. J. 2000; 21(17):1399-1401.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">O’Shea J.C., Calif R.M. Inter-regional differences in acute coronary syndrome trials. Eur Hear. J. 2000;21(17):1397-1399.</mixed-citation><mixed-citation xml:lang="en">O’Shea J.C., Calif R.M. Inter-regional differences in acute coronary syndrome trials. Eur Hear. J. 2000;21(17):1397-1399.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Гафаров В.В., Гафарова А.В, Благинина М.Ю. Программа ВОЗ «Регистр острого инфаркта миокарда»: 25-летнее эпидемиологическое исследованиеинфаркта миокарда в России (1977-2001). Кардиология. 2005;8: 48-50.</mixed-citation><mixed-citation xml:lang="en">Gafarov V.V., Gafarova A.V., Blaginina M.Yu. The WHO program “Register of acute myocardial infarction”: a 25-year epidemiological study of myocardial infarction in Russia (1977-2001). Cardiology. 2005;8:48-50 [in Russian].</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Космачева Е.Д., Позднякова О.А, Круберг Л.К. и соавт. Первые результаты регистра острых коронарных синдромов в Краснодарском крае. Атеротромбоз. 2010;1(4):109-114</mixed-citation><mixed-citation xml:lang="en">Kosmacheva E.D., Pozdnyakova O.A., Kruberg L.K. et al. The first results of the register of acute coronary syndromes in the Krasnodar region. Atherothrombosis. 2010;1(4):109-114 [in Russian].</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ощепкова Е.В. Смертность населения от сердечно-сосудистых заболеваний в Российской Федерации и пути по ее снижению. Кардиология. 2009. 2:267-272</mixed-citation><mixed-citation xml:lang="en">Oshchepkova E.V. Mortality of the population from cardiovascular diseases in the Russian Federation and ways to reduce it. Cardiology. 2009.2:267-272 [in Russian].</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Эрлих А.Д., Грацианский Н.А. Острый коронарный синдром без подъемов ST в реальной практике российских стационаров. Сравнительные данные регистров «РЕКОРД-2» и «РЕКОРД». Кардиология. 2012;10:9-16</mixed-citation><mixed-citation xml:lang="en">Erlich A.D., Gratsiansky N.A. Acute coronary syndrome without ST elevations in the real practice of Russian hospitals. Comparative data registers “RECORD-2” and “RECORD”. Cardiology. 2012;10:9-16 [in Russian].</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Granger C.B., Goldberg R.J., Dabbous O.M. et al. Predictors of hospital mortality in the Global Registry of Acute Coronary Events. Arch Int Med. 2003;163:2345-53.</mixed-citation><mixed-citation xml:lang="en">Granger C.B., Goldberg R.J., Dabbous O.M. et al. Predictors of hospital mortality in the Global Registry of Acute Coronary Events. Arch Int Med. 2003;163: 2345-53.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Fox K.A., Poole-Wilson P., Clayton T.C., Henderson R.A. et al. 5-year outcome of an interventional strategy in non-ST-elevationacute coronarysyndrome: the British HeartFoundation RITA 3 randomised trial/ Lancet. 2005;366(9489):914-920.</mixed-citation><mixed-citation xml:lang="en">Fox K.A., Poole-Wilson P., Clayton T.C., Henderson R.A. et al. 5-year outcome of an interventional strategy in non-STelevation acute coronary syndrome: the British Heart Foundation RITA 3 randomised trial / Lancet. 2005;366(9489):914-920.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Peterson S., Peto V, Rayner M. et al. European Cardiovascular Disease Statistics, 2nd edn. London: British Heart Foundation, 2005.</mixed-citation><mixed-citation xml:lang="en">Peterson S., Peto V., Rayner M. et al. European Cardiovascular Disease Statistics, 2nd edn. London: British Heart Foundation, 2005.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Свистов А.С, Галиуллина Р.Х., Обрезан А.Г. Особенности факторов риска ИБС, данных велоэргометрических проб, суточного мониторирования ЭКГ и коронарографии у женщин молодого возраста, перенесших инфаркт миокарда. Кардиология. 2003;3:54-58</mixed-citation><mixed-citation xml:lang="en">Svistov A.S., Galiullina R.Kh., Obrezan A.G. Features of risk factors for coronary artery disease, exercise test samples, 24-hour ECG monitoring and coronary angiography in young women with myocardial infarction. Cardiology. 2003; 3:54-58 [In Russian].</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Маколкин В.И. Оптимизация лечения стабильной стенокардии. Consilium Medicum. 2007;9(5):44-48</mixed-citation><mixed-citation xml:lang="en">Makolkin V.I. Optimization of treatment of stable angina. Consilium Medicum. 2007; 9(5):44-48 [in Russian].</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Глезер М.Г., Сайгитов Р.Т., Семенцов Д.П. и соавт. Острый коронарный синдром у пожилых: прогноз госпитальной смертности. Клин. геронт. 2005;11(1):13-20</mixed-citation><mixed-citation xml:lang="en">Gleser M.G., Saigitov R.T., Sementsov D.P. et al. Acute coronary syndrome in the elderly: a prognosis for hospital mortality. Wedge. geront. 2005; 11(1):13-20 [in Russian].</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Hasdai D., Behar S., Wallentin L. et al. A prospective survey of the characteristics, treatments and outcomes of patients with acute coronary syndromes in Europe and the Mediterranean basin; the Euro Heart Survey of Acute Coronary Syndromes. Eur Heart J. 2002; 23(15):1190-201.</mixed-citation><mixed-citation xml:lang="en">Hasdai D., Behar S., Wallentin L. et al. A prospective survey of the characteristics, treatments and outcomes of patients with acute coronary syndromes in Europe and the Mediterranean basin; the Euro Heart Survey of Acute Coronary Syndromes. Eur Heart J. 2002; 23(15):1190-201.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Hochman J.S., McCabe C.H., Stone P.H. et al. Outcome and profile of women and men presenting with acute coronary syndromes: a report from TIMIIIIB. JACC. 1997;30:141-8.</mixed-citation><mixed-citation xml:lang="en">Hochman J.S., McCabe C.H., Stone P.H. et al. Outcome and profile of women and men presenting with acute coronary syndromes: a report from TIMI IIIB. JACC. 1997;30:141-8.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Rosengren A, Wallentin L., Gitt A. et al. Sex, age, and clinical presentation of acute coronary syndromes. Eur Heart J. 2004; 25(8):663-670.</mixed-citation><mixed-citation xml:lang="en">Rosengren A., Wallentin L., Gitt A. et al. Sex, age, and clinical presentation of acute coronary syndromes. Eur Heart J. 2004; 25(8):663-670.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Fiebach N.H., Viscoli C.M., Horwitz R.I. Differences between women and men in survival after myocardial infarction. Biology or methodology? JAMA. 1990; 263(8):1092-1096.</mixed-citation><mixed-citation xml:lang="en">Fiebach N.H., Viscoli C.M., Horwitz R.I. Differences between women and men in survival after myocardial infarction. Biology or methodology? JAMA. 1990; 263(8):1092-1096.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Wang W, Lau Y., Loo A. et al. Medication adherence and its associated factors among Chinese community-dwelling older adults with hypertension. Heart Lung. 2014; 43(4):278-283.</mixed-citation><mixed-citation xml:lang="en">Wang W., Lau Y., Loo A. et al. Medication adherence and its associated factors among Chinese community-dwelling older adults with hypertension. Heart Lung. 2014; 43(4):278-283.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Fodor G.J., Kotrec M., Bacskai K. et al. Is interview a reliable method to verify the compliance with antihypertensive therapy? An international Central-European study. J Hypertens. 2005; 23:1261-1266.</mixed-citation><mixed-citation xml:lang="en">Fodor G.J., Kotrec M., Bacskai K. et al. Is interview a reliable method to verify the compliance with antihypertensive therapy? An international Central-European study. J Hypertens. 2005; 23:1261-1266.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Rao C.R., Veena K.G., Shetty A. et al. Treatment Compliance among patients with hypertension and type 2 diabetes mellitus in a coastal population of Southern India. Int J Prev Med. 2014; 5(8):992-998.</mixed-citation><mixed-citation xml:lang="en">Rao C.R., Veena K.G., Shetty A. et al. Treatment Compliance among patients with hypertension and type 2 diabetes mellitus in a coastal population of Southern India. Int J Prev Med. 2014; 5(8):992-998.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Raymundo NAC, Pierin AMG. Adherence to anti-hypertensive treatment within a chronic disease management program: A longitudinal, retrospective study. Rev Esc Enferm USP. 2014; 48(5):809-817.</mixed-citation><mixed-citation xml:lang="en">Raymundo NAC, Pierin AMG. Adherence to anti-hypertensive treatment within a chronic disease management program: A longitudinal, retrospective study. Rev Esc Enferm USP. 2014; 48(5):809-817</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
